| Gene Symbol |
CAPZA3
|
| Entrez Gene |
93661
|
| Alt Symbol |
CAPPA3, Gsg3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
capping protein (actin filament) muscle Z-line, alpha 3
|
| Other Description |
CP-alpha-3|CapZ alpha-3|F-actin capping protein alpha-3 subunit|F-actin-capping protein subunit alpha-3|germ cell-specific protein 3
|
| Swissprots |
Q96KX2 Q969J0
|
| Accessions |
CBH19237 EAW96391 Q96KX2 AB053259 BAB61901 AK058174 BAB71703 BC016745 AAH16745 BG772483 JF432140 ADZ15357 NM_033328 NP_201585
|
| Function |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region. {ECO:0000269|PubMed:12029070}.
|