| Gene Symbol |
CTC1
|
| Entrez Gene |
80169
|
| Alt Symbol |
AAF-132, AAF132, C17orf68, CRMCC, tmp494178
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTS telomere maintenance complex component 1
|
| Other Description |
CST complex subunit CTC1|HBV DNAPTP1-transactivated protein B|alpha accessory factor 132|conserved telomere capping protein 1
|
| Swissprots |
Q1PCD1 Q2TBE3 C9JEX5 B3KR66 Q2NKJ3 Q9H6L0 Q8N3S6
|
| Accessions |
EAW90070 EAW90071 Q2NKJ3 AK025823 BAB15247 AK091077 BAG52278 AK225375 AK310636 AL831955 CAD38600 BC026057 AAH26057 BC110373 AAI10374 BC111783 AAI11784 BF798182 BU631459 BX406692 DA313518 DB126489 DQ451688 ABE02809 FJ790670 ACY71127 HG508640 XM_006721577 XP_006721640 XM_006721578 XP_006721641 XM_006721579 XP_006721642 XM_011524010 XP_011522312 XM_011524011 XP_011522313 XR_429823 XR_429824 XR_429825 NM_025099 NP_079375 NR_046431
|
| Function |
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:19854131}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
|