| Gene Symbol |
KLF10
|
| Entrez Gene |
7071
|
| Alt Symbol |
EGR-alpha, EGRA, TIEG, TIEG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kruppel-like factor 10
|
| Other Description |
Krueppel-like factor 10|TGFB-inducible early growth response protein 1|early growth response-alpha|transforming growth factor-beta-inducible early growth response protein 1|zinc finger transcription factor TIEG
|
| Swissprots |
O75411 B2R794 L0R4P6 A8MVH0 Q503B2 Q13118 L0R679
|
| Accessions |
AAC34293 AAC34294 EAW91850 Q13118 AK312894 BAG35741 BC011538 AAH11538 BC095399 AAH95399 BI560615 BQ575313 BT006634 AAP35280 DA720479 DA756360 EU832176 ACE87526 EU832269 ACE86839 HF546210 CCO02796 HF546211 CCO02797 HQ448295 ADQ32775 S81439 AAB36088 U21847 AAC50340 X75691 NM_001032282 NP_001027453 NM_005655 NP_005646 NR_103759 NR_103760
|
| Function |
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:O89091}.
|
![Western Blot: KLF10 Overexpression Lysate (Adult Normal) [NBL1-12312] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KLF10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6707_KLF10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12312-img0002.jpg)