Gene Symbol | KLF10 |
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Entrez Gene | 7071 |
Alt Symbol | EGR-alpha, EGRA, TIEG, TIEG1 |
Species | Human |
Gene Type | protein-coding |
Description | Kruppel-like factor 10 |
Other Description | Krueppel-like factor 10|TGFB-inducible early growth response protein 1|early growth response-alpha|transforming growth factor-beta-inducible early growth response protein 1|zinc finger transcription factor TIEG |
Swissprots | O75411 B2R794 L0R4P6 A8MVH0 Q503B2 Q13118 L0R679 |
Accessions | AAC34293 AAC34294 EAW91850 Q13118 AK312894 BAG35741 BC011538 AAH11538 BC095399 AAH95399 BI560615 BQ575313 BT006634 AAP35280 DA720479 DA756360 EU832176 ACE87526 EU832269 ACE86839 HF546210 CCO02796 HF546211 CCO02797 HQ448295 ADQ32775 S81439 AAB36088 U21847 AAC50340 X75691 NM_001032282 NP_001027453 NM_005655 NP_005646 NR_103759 NR_103760 |
Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:O89091}. |
TIEG1 CRISPR/Cas9 KO Plasmid (h) - sc-402480 from Santa Cruz Biotechnology
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TIEG1 HDR Plasmid (h) - sc-402480-HDR from Santa Cruz Biotechnology
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TIEG1 Double Nickase Plasmid (h) - sc-402480-NIC from Santa Cruz Biotechnology
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TIEG1 Double Nickase Plasmid (h2) - sc-402480-NIC-2 from Santa Cruz Biotechnology
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TIEG1 CRISPR Activation Plasmid (h) - sc-402480-ACT from Santa Cruz Biotechnology
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TIEG1 CRISPR Activation Plasmid (h2) - sc-402480-ACT-2 from Santa Cruz Biotechnology
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TIEG1 Lentiviral Activation Particles (h) - sc-402480-LAC from Santa Cruz Biotechnology
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TIEG1 Lentiviral Activation Particles (h2) - sc-402480-LAC-2 from Santa Cruz Biotechnology
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TIEG1 siRNA (h) - sc-45463 from Santa Cruz Biotechnology
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TIEG1 shRNA Plasmid (h) - sc-45463-SH from Santa Cruz Biotechnology
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TIEG1 shRNA (h) Lentiviral Particles - sc-45463-V from Santa Cruz Biotechnology
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KLF10 RNAi - H00007071-R01 from Novus Biologicals
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KLF10 RNAi - H00007071-R02 from Novus Biologicals
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MISSION® esiRNA - EHU101141 from Sigma-Aldrich
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MISSION® esiRNA - EHU086801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11244 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11244 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09149 from Sigma-Aldrich
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KLF10 siRNA (Human) - CRH4840 from Cohesion Biosciences
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TIEG1 CRISPR/Cas9 KO Plasmid (h2) - sc-402480-KO-2 from Santa Cruz Biotechnology
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TIEG1 HDR Plasmid (h2) - sc-402480-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KLF10 (NM_005655.2) - SHH325716 from Creative biogene
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Human KLF10 siRNA - orb265342 from Biorbyt
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KLF10 shRNA Plasmid (Human) - CHH4840 from Cohesion Biosciences
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KLF10 miRNA 3'UTR clone - MiUTR3H-04473 from Creative biogene
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