| Gene Symbol |
TRIP12
|
| Entrez Gene |
9320
|
| Alt Symbol |
TRIP-12, ULF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor interactor 12
|
| Other Description |
E3 ubiquitin-protein ligase TRIP12|E3 ubiquitin-protein ligase for Arf|TR-interacting protein 12|probable E3 ubiquitin-protein ligase TRIP12|thyroid receptor interacting protein 12|thyroid receptor-interacting protein 12
|
| Swissprots |
Q53R87 Q53TE7 Q14669 Q14CA3 Q15644 Q14CF1 D4HL82
|
| Accessions |
AAX82004 AAY14681 AAY14755 CCO13843 EAW70896 EAW70897 EAW70898 EAW70899 EAW70900 EAW70901 EAW70902 EAW70903 EAW70904 EAW70905 EAW70906 EAW70907 EAW70908 Q14669 AK128481 AK302468 BAG63758 AK310971 BC037956 BC113891 AAI13892 BC114556 AAI14557 BM677880 D28476 BAA05837 DB240964 EU489742 ACC99349 L40383 AAC41731 XM_005246954 XP_005247011 XM_005246955 XP_005247012 XM_005246956 XP_005247013 XM_005246957 XP_005247014 XM_005246958 XP_005247015 XM_005246960 XP_005247017 XM_005246961 XP_005247018 XM_005246962 XP_005247019 XM_005246963 XP_005247020 XM_006712852 XP_006712915 XM_006712853 XP_006712916 XM_011512180 XP_011510482 XM_011512181 XP_011510483 XM_011512182 XP_011510484 XM_011512183 XP_011510485 XM_011512184 XP_011510486 NM_001284214 NP_001271143 NM_001284215 NP_001271144 NM_001284216 NP_001271145 NM_004238 NP_004229
|
| Function |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regul
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:20208519}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|