TRIP12

Gene Symbol TRIP12
Entrez Gene 9320
Alt Symbol TRIP-12, ULF
Species Human
Gene Type protein-coding
Description thyroid hormone receptor interactor 12
Other Description E3 ubiquitin-protein ligase TRIP12|E3 ubiquitin-protein ligase for Arf|TR-interacting protein 12|probable E3 ubiquitin-protein ligase TRIP12|thyroid receptor interacting protein 12|thyroid receptor-interacting protein 12
Swissprots Q53R87 Q53TE7 Q14669 Q14CA3 Q15644 Q14CF1 D4HL82
Accessions AAX82004 AAY14681 AAY14755 CCO13843 EAW70896 EAW70897 EAW70898 EAW70899 EAW70900 EAW70901 EAW70902 EAW70903 EAW70904 EAW70905 EAW70906 EAW70907 EAW70908 Q14669 AK128481 AK302468 BAG63758 AK310971 BC037956 BC113891 AAI13892 BC114556 AAI14557 BM677880 D28476 BAA05837 DB240964 EU489742 ACC99349 L40383 AAC41731 XM_005246954 XP_005247011 XM_005246955 XP_005247012 XM_005246956 XP_005247013 XM_005246957 XP_005247014 XM_005246958 XP_005247015 XM_005246960 XP_005247017 XM_005246961 XP_005247018 XM_005246962 XP_005247019 XM_005246963 XP_005247020 XM_006712852 XP_006712915 XM_006712853 XP_006712916 XM_011512180 XP_011510482 XM_011512181 XP_011510483 XM_011512182 XP_011510484 XM_011512183 XP_011510485 XM_011512184 XP_011510486 NM_001284214 NP_001271143 NM_001284215 NP_001271144 NM_001284216 NP_001271145 NM_004238 NP_004229
Function E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regul
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:20208519}.
Top Pathways Ubiquitin mediated proteolysis

TRIP12 (E-14) - sc-138710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TRIP12 (E-14): sc-138710. Western blot analysis of TRIP12 expression in HL-60 nuclear extract.

TRIP12 (C-15) - sc-138709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-TRIP12 antibody - ab86220 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRIP12 antibody (ab86220) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 5 µgLane 2 : HeLa whole cell lysate at 1.5 µgLane 3 : HeLa whole cell lysate at 0.5 µgdeveloped using the ECL technique

Anti-TRIP12 Antibody (aa75-125) - LS-C288592 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human TRIP12 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (0.5, 1.5 and 5 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibody: Affinity purified rabbit anti-TRIP12 antibody used for WB at 0.04 ug/ml (A) and 0.1 ug/ml (B) and used for IP at 3 ug/mg lysate. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 second (B).

Anti-TRIP12 Antibody IHC-plus™ - LS-B7823 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIP12 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7823 dilution 5 ug/ml.

Anti-TRIP12 Antibody (C-Terminus) IHC-plus™ - LS-B12129 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of TRIP12 in rat colon tissue with TRIP12 antibody at 5 ug/ml.

Thyroid receptor-interacting protein 12 Antibody - NB100-97822 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Thyroid receptor-interacting protein 12 Antibody [NB100-97822] - Detection of Human TRIP12 on HeLa whole cell lysate using NB100-97822.

Thyroid receptor-interacting protein 12 Antibody - NBP2-33450 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Thyroid receptor-interacting protein 12 Antibody [NBP2-33450] - Staining of testis cancer.

Thyroid receptor-interacting protein 12 Antibody - NBP2-34035 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Thyroid receptor-interacting protein 12 Antibody [NBP2-34035] - Staining of human cell line U-2 OS shows localization to nuclear speckles.

Anti-TRIP12 antibody produced in rabbit - SAB2900921 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRIP12, antibody produced in rabbit: <B>Cat. No. SAB2900921</B>: Anti-TRIP12 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 μg/mL.

Anti-TRIP12 antibody produced in rabbit - HPA045893 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRIP12: <B>Cat. No. HPA045893</B>: Immunohistochemical staining of Human colon shows moderate nuclear positivity in glandular cells.

Anti-TRIP12 antibody produced in rabbit - SAB2900830 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRIP12 (C-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900830</B>: Anti-TRIP12 antibody IHC staining of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 μg/mL.

Anti-TRIP12 antibody produced in rabbit - HPA036835 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRIP12: <B>Cat. No. HPA036835</B>: Immunohistochemical staining of Human colon shows moderate nuclear positivity in glandular cells.

TRIP12 antibody - orb186368 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human TRIP12 - 119-16705 from RayBiotech

Host Rabbit

TRIP12 Antibody - 7953 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of TRIP12 in rat colon tissue lysate with TRIP12 antibody at 1 μg/ml.

TRIP12, Polyclonal Antibody - MBS153608 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

TRIP12, Polyclonal Antibody - MBS244805 from MyBioSource

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

TRIP12, Polyclonal Antibody - MBS643483 from MyBioSource

Prices $590.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

TRIP12 Antibody - A301-814A from Bethyl Labs

Prices $99.00, $229.00, $339.00
Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (0.2 mg/ml)
Host Rabbit
Clonality Polyclonal

TRIP12 Antibody - 600-401-FQ1 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TRIP12 antibody - pab73714 from Covalab

Host Rabbit
Clonality Polyclonal

Anti-TRIP12 Antibody (aa75-125) IHC-plus™ - LS-B12675 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

TRIP12 Antibody (OALA06535) - OALA06535 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIP12-Antibody-ALS15172 - ALS15172 from Abgent, a WuXi AppTec company

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRIP12 antibody IHC of human prostate.
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