Gene Symbol | E2F2 |
---|---|
Entrez Gene | 1870 |
Alt Symbol | E2F-2 |
Species | Human |
Gene Type | protein-coding |
Description | E2F transcription factor 2 |
Other Description | transcription factor E2F2 |
Swissprots | Q14209 B2R9W1 Q7Z6H1 |
Accessions | AAM54044 EAW95055 EAW95056 EAW95057 EAW95058 Q14209 AF086395 AK092799 AK313939 BAG36658 BC007609 AAH07609 BC053676 AAH53676 BT019523 AAV38330 L22846 AAA16890 XM_005245748 XP_005245805 XM_005245749 XP_005245806 XM_011540868 XP_011539170 XM_011540869 XP_011539171 XM_011540870 XP_011539172 XM_011540871 XP_011539173 NM_004091 NP_004082 |
Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. |
Subcellular Location | Nucleus. |
Tissue Specificity | Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples. |
Top Pathways | MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma |
E2F-2 CRISPR/Cas9 KO Plasmid (h) - sc-400880 from Santa Cruz Biotechnology
|
||||||||
E2F-2 HDR Plasmid (h) - sc-400880-HDR from Santa Cruz Biotechnology
|
||||||||
E2F-2 Double Nickase Plasmid (h) - sc-400880-NIC from Santa Cruz Biotechnology
|
||||||||
E2F-2 Double Nickase Plasmid (h2) - sc-400880-NIC-2 from Santa Cruz Biotechnology
|
||||||||
E2F-2 CRISPR Activation Plasmid (h) - sc-400880-ACT from Santa Cruz Biotechnology
|
||||||||
E2F-2 CRISPR Activation Plasmid (h2) - sc-400880-ACT-2 from Santa Cruz Biotechnology
|
||||||||
E2F-2 Lentiviral Activation Particles (h) - sc-400880-LAC from Santa Cruz Biotechnology
|
||||||||
E2F-2 Lentiviral Activation Particles (h2) - sc-400880-LAC-2 from Santa Cruz Biotechnology
|
||||||||
E2F-2 siRNA (h) - sc-29298 from Santa Cruz Biotechnology
|
||||||||
E2F-2 shRNA Plasmid (h) - sc-29298-SH from Santa Cruz Biotechnology
|
||||||||
E2F-2 shRNA (h) Lentiviral Particles - sc-29298-V from Santa Cruz Biotechnology
|
||||||||
E2F-2 RNAi - H00001870-R01 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN7605 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7605 from Sigma-Aldrich
|
||||||||
E2F2 siRNA (Human) - CRH1307 from Cohesion Biosciences
|
||||||||
E2F2 - MBS8214676 from MyBioSource
|
||||||||
shRNA set against Human E2F2 (NM_004091.3) - SHH282501 from Creative biogene
|
||||||||
Human E2F2 siRNA - orb261809 from Biorbyt
|
||||||||
E2F2 shRNA Plasmid (Human) - CHH1307 from Cohesion Biosciences
|
||||||||
E2F2 miRNA 3'UTR clone - MiUTR4H-TG02933 from Creative biogene
|