GNA13
| Gene Symbol | GNA13 |
|---|---|
| Entrez Gene | 10672 |
| Alt Symbol | G13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein (G protein), alpha 13 |
| Other Description | G-protein subunit alpha-13|g alpha-13|guanine nucleotide-binding protein subunit alpha-13 |
| Swissprots | Q14344 Q8TD70 F5H1G8 B7Z7R0 B2R977 |
| Accessions | EAW88993 EAW88994 EAW88995 EAW88996 Q14344 AB075500 AF493902 AAM12616 AK002117 AK026902 AK301699 BAG63171 AK302400 BAH13696 AK313672 BAG36424 AW298099 BC036756 AAH36756 DC335364 DQ893572 ABM84498 DQ894448 ABM85374 L22075 AAA74235 XM_011524202 XP_011522504 XR_934352 NM_001282425 NP_001269354 NM_006572 NP_006563 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| Subcellular Location | Membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei. |
| Tissue Specificity | Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level). {ECO:0000269|PubMed:18703424}. |
| Top Pathways | Long-term depression, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Regulation of actin cytoskeleton |
G α 13 CRISPR/Cas9 KO Plasmid (h) - sc-401180 from Santa Cruz Biotechnology
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G α 13 HDR Plasmid (h) - sc-401180-HDR from Santa Cruz Biotechnology
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G α 13 Double Nickase Plasmid (h) - sc-401180-NIC from Santa Cruz Biotechnology
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G α 13 Double Nickase Plasmid (h2) - sc-401180-NIC-2 from Santa Cruz Biotechnology
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G α 13 CRISPR Activation Plasmid (h) - sc-401180-ACT from Santa Cruz Biotechnology
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G α 13 CRISPR Activation Plasmid (h2) - sc-401180-ACT-2 from Santa Cruz Biotechnology
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G α 13 Lentiviral Activation Particles (h) - sc-401180-LAC from Santa Cruz Biotechnology
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G α 13 Lentiviral Activation Particles (h2) - sc-401180-LAC-2 from Santa Cruz Biotechnology
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G α 13 siRNA (h) - sc-35427 from Santa Cruz Biotechnology
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G α 13 shRNA Plasmid (h) - sc-35427-SH from Santa Cruz Biotechnology
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G α 13 shRNA (h) Lentiviral Particles - sc-35427-V from Santa Cruz Biotechnology
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G protein alpha-13 RNAi - H00010672-R01 from Novus Biologicals
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MISSION® esiRNA - EHU018081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9401 from Sigma-Aldrich
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GNA13 siRNA (Human) - CRH7279 from Cohesion Biosciences
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GNA13 - MBS8207766 from MyBioSource
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shRNA set against Human GNA13 (NM_006572.4) - SHH304582 from Creative biogene
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GNA13 shRNA Plasmid (Human) - CHH7279 from Cohesion Biosciences
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GNA13 miRNA 3'UTR clone - MiUTR4H-TG03878 from Creative biogene
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