| Gene Symbol | PGLYRP3 |
|---|---|
| Entrez Gene | 114771 |
| Alt Symbol | PGLYRPIalpha, PGRP-Ialpha, PGRPIA |
| Species | Human |
| Gene Type | protein-coding |
| Description | peptidoglycan recognition protein 3 |
| Other Description | peptidoglycan recognition protein I alpha|peptidoglycan recognition protein intermediate alpha |
| Swissprots | A1A4U8 Q5SY65 Q96LB9 |
| Accessions | EAW53338 Q96LB9 AY035376 AAK72484 BC069741 AAH69741 BC069798 AAH69798 BC069801 AAH69801 BC128114 AAI28115 BC128115 AAI28116 HQ447482 ADQ31968 XM_011509118 XP_011507420 XM_011509119 XP_011507421 XM_011509120 XP_011507422 XR_921736 NM_052891 NP_443123 |
| Function | Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:16354652}. |
| Tissue Specificity | Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}. |