Gene Symbol | CNTNAP1 |
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Entrez Gene | 8506 |
Alt Symbol | CASPR, CNTNAP, NRXN4, P190 |
Species | Human |
Gene Type | protein-coding |
Description | contactin associated protein 1 |
Other Description | caspr1|contactin-associated protein 1|neurexin IV|neurexin-4 |
Swissprots | P78357 |
Accessions | CCQ43225 EAW60867 EAW60868 EAW60869 P78357 BC160132 AAI60132 BC171797 BU729460 U87223 AAB48481 XM_005257748 XP_005257805 NM_003632 NP_003623 |
Function | Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. |
Top Pathways | Cell adhesion molecules (CAMs) |
CASPR CRISPR/Cas9 KO Plasmid (h) - sc-402760 from Santa Cruz Biotechnology
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CASPR HDR Plasmid (h) - sc-402760-HDR from Santa Cruz Biotechnology
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CASPR Double Nickase Plasmid (h) - sc-402760-NIC from Santa Cruz Biotechnology
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CASPR Double Nickase Plasmid (h2) - sc-402760-NIC-2 from Santa Cruz Biotechnology
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CASPR CRISPR Activation Plasmid (h) - sc-402760-ACT from Santa Cruz Biotechnology
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CASPR CRISPR Activation Plasmid (h2) - sc-402760-ACT-2 from Santa Cruz Biotechnology
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CASPR Lentiviral Activation Particles (h) - sc-402760-LAC from Santa Cruz Biotechnology
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CASPR Lentiviral Activation Particles (h2) - sc-402760-LAC-2 from Santa Cruz Biotechnology
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CASPR siRNA (h) - sc-41915 from Santa Cruz Biotechnology
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CASPR shRNA Plasmid (h) - sc-41915-SH from Santa Cruz Biotechnology
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CASPR shRNA (h) Lentiviral Particles - sc-41915-V from Santa Cruz Biotechnology
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Caspr1 RNAi - H00008506-R02 from Novus Biologicals
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MISSION® esiRNA - EHU017801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6346 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6346 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07009 from Sigma-Aldrich
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CNTNAP1 siRNA (Human) - CRH5580 from Cohesion Biosciences
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CNTNAP1 - MBS8201435 from MyBioSource
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shRNA set against Human CNTNAP1 (NM_003632.2) - SHH266741 from Creative biogene
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Human CNTNAP1 siRNA - orb266082 from Biorbyt
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CNTNAP1 shRNA Plasmid (Human) - CHH5580 from Cohesion Biosciences
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CNTNAP1 miRNA 3'UTR clone - MiUTR3H-04898 from Creative biogene
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