GBA3

Gene Symbol GBA3
Entrez Gene 57733
Alt Symbol CBG, CBGL1, GLUC, KLRP
Species Human
Gene Type protein-coding
Description glucosidase, beta, acid 3 (gene/pseudogene)
Other Description cytosolic beta-glucosidase|cytosolic beta-glucosidase-like protein 1|glucosidase, beta, acid 3 (cytosolic)|klotho-related protein
Swissprots Q9H3T4 Q9H4C6 Q3MIH4 Q9H227 Q32LY7 Q8NHT8 Q53GG8 Q6NSF4
Accessions EAW92802 EAW92803 Q9H227 AB017913 BAB18741 AF317840 AAG39217 AF323990 AAL37305 AJ278964 CAC08178 AK222963 BAD96683 AK292746 BAF85435 AK298377 BAH12772 AK313189 BAG36006 BC029362 AAH29362 BC070188 AAH70188 BC101829 AAI01830 BC109377 AAI09378 BC136264 AAI36265 BP383134 CB163648 NM_001128432 NP_001121904 NM_001277225 NP_001264154 NM_020973 NP_066024 NR_102355 NR_102356 NR_102357
Function Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. {ECO:0000269|PubMed:11784319, ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}.
Tissue Specificity Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. {ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:12594539}.
Top Pathways Cyanoamino acid metabolism, Starch and sucrose metabolism

CBG (C-20) - sc-51262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBG (C-20): sc-51262. Western blot analysis of CBG expression in human liver tissue extract.

CBG (H-76) - sc-367162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBG (H-76): sc-367162. Western blot analysis of CBG expression in HeLa whole cell lysate (A) and human liver tissue extract (B).

CBG (K-19) - sc-51263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBG (K-19): sc-51263. Western blot analysis of CBG expression in ECV304 whole cell lysate.

CBG (N-19) - sc-51264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CBG (V-18) - sc-51265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GBA3 antibody - ab154897 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GBA3 antibody (ab154897) at 1/500 dilution + Jurkat whole cell lysate at 30 µg

Anti-GBA3 antibody - ab136243 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GBA3 antibody (ab136243) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-GBA3 antibody - ab71975 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-GBA3 antibody (ab71975) at 1/500 dilutionLane 1 : GBA3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L) HRP conjugate at 1/2500 dilution

Anti-GBA3 antibody - ab118947 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GBA3 antibody (ab118947) at 1 µg/ml + HeLa cell lysate at 10 µg

Anti-GBA3 antibody [4C7] - ab119192 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C7
All lanes : Anti-GBA3 antibody [4C7] (ab119192) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY GBA3 cDNALysates/proteins at 5 µg per lane.

Anti-GBA3 antibody [5G5] - ab119309 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G5
All lanes : Anti-GBA3 antibody [5G5] (ab119309) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY GBA3 cDNALysates/proteins at 5 µg per lane.

Anti-GBA3 antibody - C-terminal - ab170664 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labeling GBA3 with ab170664 at 1/10 dilution, followed by a peroxidase conjugated secondary antibody and DAB staining.

Anti-GBA3 / CBG Antibody (clone 1F1) - LS-C172793 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F1
IHC of paraffin-embedded Human lymph node tissue using anti-GBA3 mouse monoclonal antibody.

Anti-GBA3 / CBG Antibody (clone 4F10) - LS-C172841 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F10
Western blot of extracts (35 ug) from 9 different cell lines by using anti-GBA3 monoclonal antibody.

Anti-GBA3 / CBG Antibody (clone 1C7) - LS-C172795 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GBA3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GBA3.

Anti-GBA3 / CBG Antibody (aa71-120) - LS-C116682 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GBA3 antibody LS-C116682 Western blot of HeLa lysate.

Anti-GBA3 / CBG Antibody (aa296-325, APC) - LS-C235553 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa296-325, AP) - LS-C235554 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa296-325, Biotin) - LS-C235555 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa296-325, FITC) - LS-C235556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa296-325, PE) - LS-C235560 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa296-325, Azide-free, HRP) - LS-C249041 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa291-340) - LS-C119890 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HUVEC cells, using GBA3 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-GBA3 / CBG Antibody - LS-C308062 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GBA3 / CBG Antibody (aa277-326) - LS-C291979 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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