| Gene Symbol | GBA3 |
|---|---|
| Entrez Gene | 57733 |
| Alt Symbol | CBG, CBGL1, GLUC, KLRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucosidase, beta, acid 3 (gene/pseudogene) |
| Other Description | cytosolic beta-glucosidase|cytosolic beta-glucosidase-like protein 1|glucosidase, beta, acid 3 (cytosolic)|klotho-related protein |
| Swissprots | Q9H3T4 Q9H4C6 Q3MIH4 Q9H227 Q32LY7 Q8NHT8 Q53GG8 Q6NSF4 |
| Accessions | EAW92802 EAW92803 Q9H227 AB017913 BAB18741 AF317840 AAG39217 AF323990 AAL37305 AJ278964 CAC08178 AK222963 BAD96683 AK292746 BAF85435 AK298377 BAH12772 AK313189 BAG36006 BC029362 AAH29362 BC070188 AAH70188 BC101829 AAI01830 BC109377 AAI09378 BC136264 AAI36265 BP383134 CB163648 NM_001128432 NP_001121904 NM_001277225 NP_001264154 NM_020973 NP_066024 NR_102355 NR_102356 NR_102357 |
| Function | Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. {ECO:0000269|PubMed:11784319, ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}. |
| Tissue Specificity | Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. {ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:12594539}. |
| Top Pathways | Cyanoamino acid metabolism, Starch and sucrose metabolism |