| Gene Symbol |
DND1
|
| Entrez Gene |
373863
|
| Alt Symbol |
RBMS4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DND microRNA-mediated repression inhibitor 1
|
| Other Description |
RNA-binding motif, single-stranded-interacting protein 4|dead end homolog 1|dead end protein homolog 1
|
| Swissprots |
Q8IYX4
|
| Accessions |
EAW62027 Q8IYX4 AY321065 AAQ63635 BC033496 AAH33496 DQ892455 ABM83381 DQ895667 ABM86593 EU176217 ABW03668 NM_194249 NP_919225
|
| Function |
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.
|