Gene Symbol | DND1 |
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Entrez Gene | 373863 |
Alt Symbol | RBMS4 |
Species | Human |
Gene Type | protein-coding |
Description | DND microRNA-mediated repression inhibitor 1 |
Other Description | RNA-binding motif, single-stranded-interacting protein 4|dead end homolog 1|dead end protein homolog 1 |
Swissprots | Q8IYX4 |
Accessions | EAW62027 Q8IYX4 AY321065 AAQ63635 BC033496 AAH33496 DQ892455 ABM83381 DQ895667 ABM86593 EU176217 ABW03668 NM_194249 NP_919225 |
Function | RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}. |
DND1 CRISPR/Cas9 KO Plasmid (h) - sc-404161 from Santa Cruz Biotechnology
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DND1 HDR Plasmid (h) - sc-404161-HDR from Santa Cruz Biotechnology
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DND1 Double Nickase Plasmid (h) - sc-404161-NIC from Santa Cruz Biotechnology
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DND1 Double Nickase Plasmid (h2) - sc-404161-NIC-2 from Santa Cruz Biotechnology
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DND1 CRISPR Activation Plasmid (h) - sc-404161-ACT from Santa Cruz Biotechnology
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DND1 CRISPR Activation Plasmid (h2) - sc-404161-ACT-2 from Santa Cruz Biotechnology
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DND1 Lentiviral Activation Particles (h) - sc-404161-LAC from Santa Cruz Biotechnology
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DND1 Lentiviral Activation Particles (h2) - sc-404161-LAC-2 from Santa Cruz Biotechnology
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DND1 siRNA (h) - sc-91708 from Santa Cruz Biotechnology
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DND1 shRNA Plasmid (h) - sc-91708-SH from Santa Cruz Biotechnology
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DND1 shRNA (h) Lentiviral Particles - sc-91708-V from Santa Cruz Biotechnology
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Dnd1 RNAi - H00373863-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7394 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7394 from Sigma-Aldrich
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DND1 siRNA (Human) - CRJ7607 from Cohesion Biosciences
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DND1 - MBS8238229 from MyBioSource
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shRNA set against Human DND1 (NM_194249.2) - SHH279865 from Creative biogene
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Human DND1 siRNA - orb278108 from Biorbyt
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DND1 shRNA Plasmid (Human) - CHJ7607 from Cohesion Biosciences
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DND1 miRNA 3'UTR clone - MiUTR3H-10574 from Creative biogene
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