Gene Symbol | Grin2a |
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Entrez Gene | 14811 |
Alt Symbol | GluN2A, NMDAR2A, NR2A |
Species | Mouse |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
Other Description | GluRepsilon1|N-methyl D-aspartate receptor subtype 2A|glutamate [NMDA] receptor subunit epsilon-1|glutamate receptor ionotropic, NMDA 2A |
Swissprots | P35436 |
Accessions | P35436 AK086290 AK149258 BC146289 AAI46290 BC148800 AAI48801 D10217 BAA01069 XM_006521794 XP_006521857 XM_006521795 XP_006521858 NM_008170 NP_032196 |
Function | NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14602821}; Multi-pass membrane protein {ECO:0000269|PubMed:14602821}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:14602821}; Multi-pass membrane protein {ECO:0000269|PubMed:14602821}. |
Top Pathways | Rap1 signaling pathway, Alcoholism, Cocaine addiction, Circadian entrainment, cAMP signaling pathway |
NMDAε1 CRISPR/Cas9 KO Plasmid (m) - sc-420689 from Santa Cruz Biotechnology
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NMDAε1 HDR Plasmid (m) - sc-420689-HDR from Santa Cruz Biotechnology
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NMDAε1 Double Nickase Plasmid (m) - sc-420689-NIC from Santa Cruz Biotechnology
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NMDAε1 Double Nickase Plasmid (m2) - sc-420689-NIC-2 from Santa Cruz Biotechnology
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NMDAε1 CRISPR Activation Plasmid (m) - sc-420689-ACT from Santa Cruz Biotechnology
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NMDAε1 CRISPR Activation Plasmid (m2) - sc-420689-ACT-2 from Santa Cruz Biotechnology
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NMDAε1 Lentiviral Activation Particles (m) - sc-420689-LAC from Santa Cruz Biotechnology
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NMDAε1 Lentiviral Activation Particles (m2) - sc-420689-LAC-2 from Santa Cruz Biotechnology
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NMDAε1 siRNA (m) - sc-36084 from Santa Cruz Biotechnology
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NMDAε1 shRNA Plasmid (m) - sc-36084-SH from Santa Cruz Biotechnology
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NMDAε1 shRNA (m) Lentiviral Particles - sc-36084-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU051581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32845 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32845 from Sigma-Aldrich
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GRIN2A siRNA (Mouse) - CRM1693 from Cohesion Biosciences
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GRIN2A - MBS8213467 from MyBioSource
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shRNA set against Mouse GRIN2A (NM_008170.2) - SHH307902 from Creative biogene
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shRNA set against Mouse Grin2a(NM_008170.2) - SHH104717 from Creative biogene
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GRIN2A shRNA Plasmid (Mouse) - CHM1693 from Cohesion Biosciences
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GRIN2A miRNA 3'UTR clone - MiUTR1M-05379 from Creative biogene
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