| Gene Symbol |
PAM
|
| Entrez Gene |
5066
|
| Alt Symbol |
PAL, PHM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylglycine alpha-amidating monooxygenase
|
| Other Description |
pancreatic peptidylglycine alpha-amidating monooxygenase|peptidyl alpha-amidating enzyme|peptidyl-alpha-hydroxyglycine alpha-amidating lyase|peptidyl-glycine alpha-amidating monooxygenase|peptidylamidoglycolate lyase|peptidylglycine 2-hydroxylase|peptidylglycine alpha-hydroxylating monooxygenase
|
| Swissprots |
O43211 Q16252 Q8WVC7 Q86U53 Q16253 A6NMR0 O95080 Q54A45 Q9UCG0 P19021 A8K293
|
| Accessions |
CBX47438 CBX47439 CBX47440 CBX47441 EAW49084 EAW49085 EAW49086 EAW49087 EAW49088 EAW49089 EAW49090 EAW49091 EAW49092 P19021 AB095007 BAC22594 AF010472 AAD01439 AF035320 AAB88190 AK290158 BAF82847 AK296521 BAG59152 BC018127 AAH18127 BI966687 BT007419 AAP36087 DA240822 M37721 AAA36414 S75037 AAB32775 S75038 AAB32776 U19965 AAB91431 U19966 AAB91432 XM_006714632 XP_006714695 XM_006714634 XP_006714697 XM_006714636 XP_006714699 XM_006714638 XP_006714701 XM_006714639 XP_006714702 XM_006714640 XP_006714703 XM_011543418 XP_011541720 XM_011543419 XP_011541721 XM_011543420 XP_011541722 XM_011543421 XP_011541723 XM_011543422 XP_011541724 XM_011543423 XP_011541725 XM_011543424 XP_011541726 XM_011543425 XP_011541727 XM_011543426 XP_011541728 XM_011543427 XP_011541729 XR_948263 XR_948264 XR_948265 XR_948266 NM_000919 NP_000910 NM_001177306 NP_001170777 NM_138766 NP_620121 NM_138821 NP_620176 NM_138822 NP_620177 NR_033440
|
| Function |
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
|
| Subcellular Location |
Isoform 3: Secreted. Note=Secreted from secretory granules.
|
![Western Blot: PAM Overexpression Lysate (Adult Normal) [NBP2-05619] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PAM.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10650_PAM%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05619-img0001.jpg)