UBA2

Gene Symbol	UBA2
Entrez Gene	10054
Alt Symbol	ARX, HRIHFB2115, SAE2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 2
Other Description	SUMO-1 activating enzyme subunit 2|SUMO-activating enzyme subunit 2|SUMO1 activating enzyme subunit 2|UBA2, ubiquitin-activating enzyme E1 homolog|anthracycline-associated resistance ARX|ubiquitin-like 1-activating enzyme E1B|ubiquitin-like modifier-activating enzyme 2
Swissprots	O95605 Q6IBP6 Q59H87 Q9UED2 Q9NTJ1 B3KWB9 Q9UBT2
Accessions	Q9UBT2 AB015337 BAA34795 AB208872 BAD92109 AF079566 AAD23914 AF090384 AAD12784 AF110957 AAD24434 AK023120 BAG51158 AK024114 BAG51265 AK124730 BAG54081 AK299514 BAH13056 AK315521 BAG37902 AL136905 CAB66839 BC003153 AAH03153 BG503066 BG678201 BM556031 BT009781 AAP88783 CR456756 CAG33037 DQ893423 ABM84349 EU176757 ABW03558 U35832 AAC99992 XM_005258404 XP_005258461 XM_006722962 XP_006723025 XM_011526304 XP_011524606 XR_935712 NM_005499 NP_005490
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® UBA2 siRNA I - 7646 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® UBA2 siRNA II - 7642 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

UBA2 CRISPR/Cas9 KO Plasmid (h) - sc-404495 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 HDR Plasmid (h) - sc-404495-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 Double Nickase Plasmid (h) - sc-404495-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 Double Nickase Plasmid (h2) - sc-404495-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 CRISPR Activation Plasmid (h) - sc-404495-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 CRISPR Activation Plasmid (h2) - sc-404495-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 Lentiviral Activation Particles (h) - sc-404495-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 Lentiviral Activation Particles (h2) - sc-404495-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBA2 siRNA (h) - sc-61740 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBA2 shRNA Plasmid (h) - sc-61740-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBA2 shRNA (h) Lentiviral Particles - sc-61740-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU109721 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN22337 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22337 from Sigma-Aldrich Category ZFN Kit Prices $4,120.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05794 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05794

UBA2 siRNA (Human) - CRH6770 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBA2 - MBS8236813 from MyBioSource

UBA2 - MBS8201144 from MyBioSource

shRNA set against Human SAE2(NM_005499.2) - SHL047916 from Creative biogene Category siRNA Species Reactivities Human

Human UBA2 siRNA - orb267272 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBA2 shRNA Plasmid (Human) - CHH6770 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBA2 miRNA 3'UTR clone - MiUTR1H-09123 from Creative biogene Species Reactivities Human

Search more