Notch4

Gene Symbol Notch4
Entrez Gene 18132
Alt Symbol Int-3, Int3, N4
Species Mouse
Gene Type protein-coding
Description notch 4
Other Description Notch gene homolog 4|neurogenic locus notch homolog protein 4
Swissprots Q62389 Q9R1X0 Q9R1W9 O88316 Q62390 O35442 P31695 O88314
Accessions AAB82004 CAM18615 EDL26808 EDL26809 EDL26810 EDL26811 EDL26812 P31695 AK143484 AK166261 AK166493 BC138044 AAI38045 BC145114 M80456 AAB38377 XM_006523798 XP_006523861 XM_006525349 XP_006525412 XR_385298 XR_385939 NM_010929 NP_035059
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system. {ECO:0000250, ECO:0000269|PubMed:11344305}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch 4 CRISPR/Cas9 KO Plasmid (m) - sc-421934 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 HDR Plasmid (m) - sc-421934-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 Double Nickase Plasmid (m) - sc-421934-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 Double Nickase Plasmid (m2) - sc-421934-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 CRISPR Activation Plasmid (m) - sc-421934-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 CRISPR Activation Plasmid (m2) - sc-421934-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 Lentiviral Activation Particles (m) - sc-421934-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 Lentiviral Activation Particles (m2) - sc-421934-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 siRNA (m) - sc-40138 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Notch 4 shRNA Plasmid (m) - sc-40138-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Notch 4 shRNA (m) Lentiviral Particles - sc-40138-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU021131 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN36583 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36583 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NOTCH4 siRNA (Mouse) - CRM2812 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse NOTCH4 (NM_010929.2) - SHH353860 from Creative biogene

Category siRNA
Species Reactivities Mouse

Notch 4 CRISPR/Cas9 KO Plasmid (m2) - sc-421934-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 4 HDR Plasmid (m2) - sc-421934-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOTCH4 shRNA Plasmid (Mouse) - CHM2812 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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