| Gene Symbol |
ITGB2
|
| Entrez Gene |
3689
|
| Alt Symbol |
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
|
| Other Description |
cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin beta-2|leukocyte cell adhesion molecule CD18|leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
|
| Swissprots |
D3DSM1 Q9UD72 Q53HS5 B3KTS8 Q16418 P05107
|
| Accessions |
AAD14951 AAD14952 AAL14027 AHZ44414 AHZ44415 AHZ44416 AHZ44417 AHZ44418 AHZ44419 AHZ44420 AHZ44421 AHZ44422 AHZ44423 AHZ44424 AHZ44425 AHZ44426 AHZ44427 AHZ44428 AHZ44429 AHZ44430 AHZ44431 AHZ44432 AHZ44433 AHZ44434 AHZ44435 AHZ44436 AHZ44437 AHZ44438 AHZ44439 CAA45427 CAB90553 EAX09381 EAX09382 EAX09383 EAX09384 EAX09385 P05107 AB208909 BAD92146 AK095992 BAG53190 AK097216 AK097864 AK128344 AK222505 BAD96225 AK303488 BAG64523 AU279404 BC005861 AAH05861 BC021077 AAH21077 CA447686 DA200537 DQ892684 ABM83610 DQ895927 ABM86853 EU832617 ACE87708 EU832689 ACE87021 L78790 AAL40068 M15395 AAA59490 S81234 AAB21404 Y00057 CAA68266 XM_006724001 XP_006724064 NM_000211 NP_000202 NM_001127491 NP_001120963 NM_001303238 NP_001290167
|
| Function |
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. {ECO:0000269|PubMed:18587400}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Malaria, Legionellosis, Tuberculosis, Hippo signaling pathway, HTLV-I infection
|