ITGB2

Gene Symbol ITGB2
Entrez Gene 3689
Alt Symbol CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Species Human
Gene Type protein-coding
Description integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Other Description cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta chain, beta 2|integrin beta-2|leukocyte cell adhesion molecule CD18|leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
Swissprots D3DSM1 Q9UD72 Q53HS5 B3KTS8 Q16418 P05107
Accessions AAD14951 AAD14952 AAL14027 AHZ44414 AHZ44415 AHZ44416 AHZ44417 AHZ44418 AHZ44419 AHZ44420 AHZ44421 AHZ44422 AHZ44423 AHZ44424 AHZ44425 AHZ44426 AHZ44427 AHZ44428 AHZ44429 AHZ44430 AHZ44431 AHZ44432 AHZ44433 AHZ44434 AHZ44435 AHZ44436 AHZ44437 AHZ44438 AHZ44439 CAA45427 CAB90553 EAX09381 EAX09382 EAX09383 EAX09384 EAX09385 P05107 AB208909 BAD92146 AK095992 BAG53190 AK097216 AK097864 AK128344 AK222505 BAD96225 AK303488 BAG64523 AU279404 BC005861 AAH05861 BC021077 AAH21077 CA447686 DA200537 DQ892684 ABM83610 DQ895927 ABM86853 EU832617 ACE87708 EU832689 ACE87021 L78790 AAL40068 M15395 AAA59490 S81234 AAB21404 Y00057 CAA68266 XM_006724001 XP_006724064 NM_000211 NP_000202 NM_001127491 NP_001120963 NM_001303238 NP_001290167
Function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. {ECO:0000269|PubMed:18587400}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Malaria, Legionellosis, Tuberculosis, Hippo signaling pathway, HTLV-I infection

Phospho-CD18 (Ser756/Thr758/759) Antibody - 3441 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Integrin β2 (CTB104) - sc-8420 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (CTB104) Alexa Fluor 488: sc-8420 AF488. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3891.

Integrin β2 (N-19) - sc-6624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β2 (N-19): sc-6624. Western blot analysis of Integrin β2 expression in HL-60 (A) and mouse PBL (B) whole cell lysates.

Integrin β2 (H-120) - sc-28661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Integrin β2 (C-20) - sc-6623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Integrin β2 (K-19) - sc-6625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Integrin β2 (P4H9) - sc-13548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (P4H9) FITC: sc-13548 FITC. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG3: sc-2858.

Integrin β2 (1.BB.246) - sc-71397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (1.BB.246): sc-71397. Western blot analysis of Integrin β2 expression in HL-60 whole cell lysate.

Integrin β2 (IB4) - sc-65254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin b2 (IB4): sc-65254. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin b2 (IB4), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG2a: sc-3878

Integrin β2 (2Q822) - sc-71399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (2Q822): sc-71399. Western blot analysis of Integrin β2 expression in HL-60 whole cell lysate.

Integrin β2 (L-13) - sc-80123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (L-13): sc-80123. Western blot analysis of Integrin β2 expression in HL-60 whole cell lysate.

Integrin β2 (6A21) - sc-71398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (6A21): sc-71398. Western blot analysis of Integrin β2 expression in HL-60 whole cell lysate.

Integrin β2 (MEM-48) - sc-51652 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (MEM-48): sc-51652. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin β2 (MEM-48), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin β2 (MEM-148) - sc-51651 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β2 (MEM-148): sc-51651. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin β2 (MEM-148), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin αV/β3 (BV3) - sc-52684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αV/β3 (BV3): sc-52684 Indirect FCM analysis of ECV-304 cells stained with Integrin β3 (BV3), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Anti-CD18 (phospho S745) antibody [EP1288Y] - ab52920 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1288Y
ICC/IF image of ab52920 stained Raw 246.7 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab52920 at 1/1000 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CD18 (phospho T758) antibody - ab63388 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HepG2 cells labelled with ab63388 at 1/500 dilution. Right hand panel was treated with immunising phosphopeptide.

Anti-CD18 antibody - ab131044 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD18 antibody (ab131044) at 0.1 µg/mlLane 1 : Jurkat cell lysateLane 2 : CEM cell lysateLane 3 : HT1080 cell lysateLane 4 : SMMc cell lysateLane 5 : HeLa cell lysate

Anti-CD18 antibody - ab62685 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62685 at 1/500 - 1/1000 dilution staining CD18 in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-CD18 antibody - ab103620 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CD18 antibody (ab103620) at 1/500 dilution + Human liver tissue lysate at 50 µg

Anti-CD18 antibody - ab195994 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-CD18 antibody (ab195994) at 0.3 µg/mlLane 1 : K562 cell lysate (in RIPA buffer)Lane 2 : U937 cell lysate (in RIPA buffer)Lysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-CD18 antibody [10E12] - ab86457 from Abcam

Host Mouse
Clonality Monoclonal
Clone 10E12
Confocal immunofluorescence analysis of HL60 cells using ab86457. 1/200 dilution. (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-CD18 antibody [3EB] (Biotin) - ab52050 from Abcam

Prices $372.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 3EB

Anti-CD18 antibody [3EB] (FITC) - ab52049 from Abcam

Prices $189.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 3EB
ab52049, at a concentration of 10µl for 100µl of whole blood, staining CD18 in Peripheral Blood Lymphocytes by Flow Cytometry.

Anti-CD18 antibody [3EB] (Phycoerythrin) - ab52051 from Abcam

Prices $372.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 3EB
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