| Gene Symbol | BTNL8 |
|---|---|
| Entrez Gene | 79908 |
| Alt Symbol | BTN9.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | butyrophilin-like 8 |
| Other Description | B7-H5 costimulatory molecule|butyrophilin-like protein 8 |
| Swissprots | E9PEF6 A4QMZ8 B7Z5B1 A6NEX6 F2Z2B2 F8W712 B7Z409 Q9H730 Q6UX41 E9PG07 |
| Accessions | EAW53732 EAW53733 Q6UX41 AK025111 BAB15069 AK225213 AK296597 BAH12395 AK298687 BAH12847 AK308012 AK309639 AY358523 AAQ88887 BC119696 AAI19697 BC119697 DA425770 XM_011534649 XP_011532951 XM_011534650 XP_011532952 XM_011534651 XP_011532953 XM_011534652 XP_011532954 XM_011534653 XP_011532955 NM_001040462 NP_001035552 NM_001159707 NP_001153179 NM_001159708 NP_001153180 NM_001159709 NP_001153181 NM_001159710 NP_001153182 NM_024850 NP_079126 |
| Function | May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production. {ECO:0000269|PubMed:24036152}. |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen. {ECO:0000269|PubMed:24036152}. |