EGLN3

Gene Symbol	EGLN3
Entrez Gene	112399
Alt Symbol	HIFP4H3, HIFPH3, PHD3
Species	Human
Gene Type	protein-coding
Description	egl-9 family hypoxia-inducible factor 3
Other Description	HIF prolyl hydroxylase 3|HIF-PH3|HIF-prolyl hydroxylase 3|HPH-1|HPH-3|egl nine homolog 3|egl nine-like protein 3 isoform|hypoxia-inducible factor prolyl hydroxylase 3|prolyl hydroxylase domain-containing protein 3
Swissprots	Q3B8N4 Q9H6Z9 Q6P1R2 Q2TA79
Accessions	EAW65929 Q9H6Z9 AJ310545 CAC42511 AK025273 BAB15101 AK026918 AK123350 BAG53892 AK225473 AK296216 BAG58941 BC010992 AAH10992 BC064924 AAH64924 BC102030 AAI02031 BC105938 AAI05939 BC105939 AAI05940 BC111057 AAI11058 BG716229 BX091357 BX346941 BX354108 CR592368 DQ975379 ABM44412 XM_006720015 XP_006720078 NM_001308103 NP_001295032 NM_022073 NP_071356
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limi
Subcellular Location	Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm. {ECO:0000250}.
Tissue Specificity	Widely expressed at low levels. Expressed at higher levels in adult heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle), lung and placenta, and in fetal spleen, heart and skeletal muscle. Also expressed in pancreas. Localized to pancreatic acini and islet cells. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12670503, ECO:0000269|PubMed:21575608}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHD3 full length protein - ab128449 from Abcam Category Protein Source E. coli Species Human

Human PHD3 peptide - ab30781 from Abcam Category Peptide

EGLN3 / PHD3 Antibody Blocking Peptide - LS-E3083 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN3 / PHD3 Antibody Blocking Peptide - LS-E26759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN3/PHD3 Partial Recombinant Protein - H00112399-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EGLN3/PHD3 Recombinant Protein - H00112399-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EGLN3-Antibody-C-term-Blocking-Peptide - BP14221b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHD3 Protein - GTX111217-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PHD3 blocking peptide - GTX88678-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human EGLN3 protein - orb168278 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Source E.coli

EGLN3 Blocking Peptide - 33R-3129 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EGLN3 protein (His tag) - 80R-2348 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

PHD3 Peptide - AC21-1594-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EGLN3 / PHD3 (1-239, His-tag) - AR50433PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

EGLN3 / PHD3 (1-239, His-tag) - AR50433PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

EGLN3 / PHD3 - H00112399-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EGLN3 / PHD3 - H00112399-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EGLN3 / PHD3 - H00112399-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EGLN3 / PHD3 - H00112399-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EGLN3, 1-239aa, Human, His tag, E.coli - 01-P1609 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

EGLN3 Peptide - 45-520P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

EGLN3 fusion protein - Ag13156 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EGLN3 fusion protein - ag13197 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

EGLN3 Human - PRPS-1150 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 2 µg, 10 µg, 100 µg Source E.coli. Species Human

Recombinant Human Egl Nine Homolog 3 Protein - BP002888-PRO-1143 from Syd Labs Category Protein Prices $160.00, $1,200.00 Sizes 10 µg, 100 µg Source E. coli-derived. Species Human

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