MAD2

Gene Symbol MAD2
Entrez Gene 853422
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description spindle checkpoint protein MAD2
Other Description -
Swissprots P40958 D6VWF2
Accessions DAA08768 P40958 NM_001181464 NP_012504
Function Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Thought to be recruited to unattached kinetochores by MAD1. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. {ECO:0000269|PubMed:15879521, ECO:0000269|PubMed:8232541}.
Subcellular Location Nucleus.
Top Pathways Cell cycle - yeast, Meiosis - yeast

Mad2 (C-3) - sc-365813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mad2 (C-3): sc-365813. Western blot analysis of Mad2 expression in S. cerevisiae whole cell lysate.

Mad2 (FL-196) - sc-25752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Mad2 (yF-19) - sc-6331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mad2 (yF-19): sc-6331. Western blot analysis of Mad2 expression in S. cerevisiae whole cell lysate.

Mad2 (yS-19) - sc-6332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mad2 (yS-19): sc-6332. Western blot analysis of Mad2 expression in EGY48 whole cell lysate.

Anti-MAD2 antibody - ab11690 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab11690 at a 1/100 dilution staining approximately 23kDa S.cerevisiae MAD2 in nucleoplasm extract, nuclear membrane extract and whole nuclear extract by Western blot (ECL).

Anti-MAD2 antibody - ab139171 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAD2 antibody (ab139171) at 1 µg/ml + Exponentially Growing WT Yeast Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Mad2 antibody - GTX80373 from GeneTex

Prices $319.00
Sizes 50 μl
Host Rabbit
Clonality Polyclonal

Mad2 antibody - IQ243 from Acris Antibodies

Prices $380.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Mad2 Antibody

Anti-S. cerevisiae MAD2 Polyclonal antibody - DPATB-H82804 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MAD2 polyclonal antibody - DPAB-DC3562 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

MAD2p Polyclonal Antibody - PA1-5834 from Thermo Fisher Scientific

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Mad2p in yeast nucleoplasm (lane 1), yeast nuclear membrane (lane 2) and yeast whole nuclei (lane 3) using Mad2p polyclonal antibody (Product # PA1-5834) at a dilution of 1:100.
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