MAD2

Gene Symbol MAD2
Entrez Gene 853422
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description spindle checkpoint protein MAD2
Other Description -
Swissprots P40958 D6VWF2
Accessions DAA08768 P40958 NM_001181464 NP_012504
Function Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Thought to be recruited to unattached kinetochores by MAD1. During checkpoint activity, MAD2 is relayed from the MAD1-MAD2 complex to the mitotic checkpoint complex (MCC). MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. {ECO:0000269|PubMed:15879521, ECO:0000269|PubMed:8232541}.
Subcellular Location Nucleus.
Top Pathways Cell cycle - yeast, Meiosis - yeast

Recombinant Saccharomyces cerevisiae Mitotic spindle checkpoint component MAD2(MAD2) - CSB-YP340327SVG CSB-EP340327SVG CSB-BP340327SVG CSB-MP340327SVG from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Yeast

Mitotic spindle checkpoint component MAD2 (MAD2), Recombinant Protein - MBS1221767 from MyBioSource

Category Protein
Prices $945.00, $945.00, $1,170.00, $1,170.00, $1,405.00, $1,405.00, $1,870.00, $1,870.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Yeast
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