Gene Symbol | SEMA6A |
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Entrez Gene | 57556 |
Alt Symbol | HT018, SEMA, SEMA6A1, SEMAQ, VIA |
Species | Human |
Gene Type | protein-coding |
Description | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
Other Description | SEMA6A-1|sema VIa|semaphorin 6A-1|semaphorin VIA|semaphorin-6A|semaphorin-6A-1 |
Swissprots | Q9P2H9 Q9H2E6 |
Accessions | EAW48934 EAW48935 EAW48936 EAW48937 EAW48938 Q9H2E6 AB037789 BAA92606 AF225425 AAG09727 AF279656 AAG29378 AI110626 AK027439 BAB55111 AK027471 BAB55136 AK027501 BAB55158 AK027505 AK027654 BAB55269 AK027867 BAB55418 AK074975 BAC11326 AK096337 BAG53263 AK302928 BAH13847 AK315143 BAG37591 AL544905 BC032619 BC156173 AAI56174 BC172468 AAI72468 CX164544 XM_005272042 XP_005272099 XM_006714663 XP_006714726 NM_020681 NM_001300780 NP_001287709 NM_020796 NP_065847 |
Function | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Axon guidance |
SEMA6A CRISPR/Cas9 KO Plasmid (h) - sc-410068 from Santa Cruz Biotechnology
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SEMA6A HDR Plasmid (h) - sc-410068-HDR from Santa Cruz Biotechnology
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SEMA6A Double Nickase Plasmid (h) - sc-410068-NIC from Santa Cruz Biotechnology
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SEMA6A Double Nickase Plasmid (h2) - sc-410068-NIC-2 from Santa Cruz Biotechnology
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SEMA6A CRISPR Activation Plasmid (h) - sc-410068-ACT from Santa Cruz Biotechnology
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SEMA6A CRISPR Activation Plasmid (h2) - sc-410068-ACT-2 from Santa Cruz Biotechnology
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SEMA6A Lentiviral Activation Particles (h) - sc-410068-LAC from Santa Cruz Biotechnology
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SEMA6A Lentiviral Activation Particles (h2) - sc-410068-LAC-2 from Santa Cruz Biotechnology
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SEMA6A siRNA (h) - sc-63004 from Santa Cruz Biotechnology
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SEMA6A shRNA Plasmid (h) - sc-63004-SH from Santa Cruz Biotechnology
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SEMA6A shRNA (h) Lentiviral Particles - sc-63004-V from Santa Cruz Biotechnology
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Semaphorin 6A RNAi - H00057556-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19078 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19078 from Sigma-Aldrich
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SEMA6A siRNA (Human) - CRJ1534 from Cohesion Biosciences
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SEMA6A - MBS8231320 from MyBioSource
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shRNA set against Human SEMA6A (NM_020796.3) - SHH404364 from Creative biogene
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shRNA set against Human SEMA6A(NM_020796.3) - SHR213996 from Creative biogene
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Human SEMA6A siRNA - orb272035 from Biorbyt
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SEMA6A shRNA Plasmid (Human) - CHJ1534 from Cohesion Biosciences
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SEMA6A miRNA 3'UTR clone - MiUTR1H-09257 from Creative biogene
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