| Gene Symbol |
Dlg4
|
| Entrez Gene |
13385
|
| Alt Symbol |
Dlgh4, PSD-95, PSD95, SAP90, SAP90A
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
discs, large homolog 4 (Drosophila)
|
| Other Description |
PSD-95 alpha 2b|PSD-95 beta|SAP-90|discs large homolog 4|disks large homolog 4|postsynaptic density protein 95|synapse-associated protein 90
|
| Swissprots |
Q91WJ1 Q5NCV6 Q5NCV5 Q62108 Q5NCV7
|
| Accessions |
AAQ56705 AAQ56706 AAQ56707 EDL12524 EDL12525 Q62108 AK028242 BC014807 AAH14807 BI738861 BQ959940 CA320223 D50621 BAA09297 XM_006532141 XP_006532204 XM_006532142 XP_006532205 XM_006532143 XP_006532206 XM_006532144 XP_006532207 XM_006532147 XP_006532210 XM_006532148 XP_006532211 XM_006532149 XP_006532212 XM_006532150 XP_006532213 XM_006537119 XP_006537182 XM_006537120 XP_006537183 XM_006537121 XP_006537184 XM_006537122 XP_006537185 XM_006537125 XP_006537188 XM_006537126 XP_006537189 XM_006537127 XP_006537190 XM_006537128 XP_006537191 XR_388345 XR_390225 NM_001109752 NP_001103222 NM_007864 NP_031890
|
| Function |
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. {ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:9853749}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000269|PubMed:24153177}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Note=Membrane- associated. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells (By similarity). {ECO:0000250}.
|
| Top Pathways |
Huntington's disease, Glutamatergic synapse, Cocaine addiction, Hippo signaling pathway
|