Dlg4

Gene Symbol Dlg4
Entrez Gene 13385
Alt Symbol Dlgh4, PSD-95, PSD95, SAP90, SAP90A
Species Mouse
Gene Type protein-coding
Description discs, large homolog 4 (Drosophila)
Other Description PSD-95 alpha 2b|PSD-95 beta|SAP-90|discs large homolog 4|disks large homolog 4|postsynaptic density protein 95|synapse-associated protein 90
Swissprots Q91WJ1 Q5NCV6 Q5NCV5 Q62108 Q5NCV7
Accessions AAQ56705 AAQ56706 AAQ56707 EDL12524 EDL12525 Q62108 AK028242 BC014807 AAH14807 BI738861 BQ959940 CA320223 D50621 BAA09297 XM_006532141 XP_006532204 XM_006532142 XP_006532205 XM_006532143 XP_006532206 XM_006532144 XP_006532207 XM_006532147 XP_006532210 XM_006532148 XP_006532211 XM_006532149 XP_006532212 XM_006532150 XP_006532213 XM_006537119 XP_006537182 XM_006537120 XP_006537183 XM_006537121 XP_006537184 XM_006537122 XP_006537185 XM_006537125 XP_006537188 XM_006537126 XP_006537189 XM_006537127 XP_006537190 XM_006537128 XP_006537191 XR_388345 XR_390225 NM_001109752 NP_001103222 NM_007864 NP_031890
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. {ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:9853749}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000269|PubMed:24153177}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Note=Membrane- associated. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells (By similarity). {ECO:0000250}.
Top Pathways Huntington's disease, Glutamatergic synapse, Cocaine addiction, Hippo signaling pathway

PSD-95 (6G6) - sc-32291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSD-95 (6G6): sc-32291. Western blot analysis of PSD-95 expression in mouse brain tissue extract.

PSD-95 (7E3) - sc-32290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSD-95 (7E3): sc-32290. Western blot analysis of PSD-95 expression in mouse brain (A) and rat brain (B) tissue extracts.

PSD-95 (6D678) - sc-71934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 (6D677) - sc-71933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 (4E182) - sc-71938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 (4E181) - sc-71937 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 (2Q128) - sc-71935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 (2Q129) - sc-71936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSD-95 Antibody (7E3-1B8) - NBP1-97531 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7E3-1B8
Western Blot: PSD95 Antibody (7E3-1B8) [NBP1-97531] - Analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).

DLG4 Antibody (OAED00229) - OAED00229 from Aviva Systems Biology

Prices $285.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7E3-1B8

DLG4 Antibody (OAED00230) - OAED00230 from Aviva Systems Biology

Prices $270.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal
Clone 6G6-1C9

PSD95 antibody, Internal (near C-Terminus) - GTX88388 from GeneTex

Prices $329.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-DLG4 / PSD95 antibody, Internal (near C-Terminus) used in Western blot. GTX88388

DLG4 / PSD95 antibody - SM5003P from Acris Antibodies

Prices $450.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7E3-1B8
Figure 1. Immunofluorescence staining of PSD-95 using SM5003P.

DLG4 / PSD95 antibody - H00001742-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot analysis of DLG4 expression in transfected 293T cell line (H00001742-T02) by DLG4 MaxPab polyclonal antibody. Lane 1: DLG4 transfected lysate(85.40 KDa). Lane 2: Non-transfected lysate.

Anti-DLG4 antibody - STJ71894 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

PSD95 antibody, pAb, Rabbit - A01501-40 from GenScript

Prices $99.00
Sizes 40 μg
Host Rabbit
Clonality Polyclonal

Rabbit anti-Mouse PSD95 (phospho S295) polyclonal antibody - DPABH-27413 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Rabbit anti-Mouse PSD95 (phospho T19) polyclonal antibody - DPABH-27414 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Rabbit anti-Mouse PSD95 (phospho S35) polyclonal antibody - DPABH-27415 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-DLG4 (aa 50-150) polyclonal antibody - DPABH-27810 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-DLG4 (aa 1-100) polyclonal antibody - DPABH-27821 from Creative Diagnostics

Host Goat
Clonality Polyclonal

Rabbit anti-Mouse PSD95 (phospho S415) polyclonal antibody - DPABH-28654 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Rabbit anti-Mouse PSD95 (phospho S418) polyclonal antibody - DPABH-28655 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Phospho-PSD-95 (Thr19) Polyclonal Antibody - PA5-19478 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse Brain Tissue Lysate using PA5-19478, PSD95 (phospho T19) primary antibody at a dilution of 1 ug/ml (lane 1). PA5-19478 staining of Mouse Forebrain Tissue Lysate at a dilution of 1 ug/ml (Lane 2). PA5-19478 staining of Rat Brain Tissue Lysate at a dilution of 1 ug/ml (lane 3). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.

PSD95 Antibody - 200-301-G32 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Immunocytochemistry of Mouse anti-PSD95 antibody. Tissue: Culutures of dissociated hippocampal neurons. Fixation: N/A Antigen retrieval: not required. Primary antibody: PSD95 antibody at 10 ug/mL for 1h at RT. Secondary antibody: Fluorescein mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: PSD95 is cell membrane and cell junctions. Staining: PSD95 as precipitated white signal.
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