CPS1

Gene Symbol CPS1
Entrez Gene 1373
Alt Symbol CPSASE1, PHN
Species Human
Gene Type protein-coding
Description carbamoyl-phosphate synthase 1, mitochondrial
Other Description carbamoyl-phosphate synthase [ammonia], mitochondrial|carbamoylphosphate synthetase I
Swissprots P31327 O43774 J3KQL0 B7Z818 Q7Z5I5 Q59HF8 Q53TL5
Accessions AAN77181 AAO31763 AAY14960 CAL39127 CCA94564 CCD32697 CCD32852 EAW70492 EAW70493 EAW70494 P31327 AB180933 BAD74204 AB180934 BAD74205 AB180935 BAD74206 AB180936 BAD74207 AB180937 BAD74208 AB180938 BAD74209 AB208800 BAD92037 AF154830 AAD38072 AK289749 BAF82438 AK302778 BAH13804 AK316425 BAH14796 AL704546 AV645723 AY317138 AAP84318 BC020695 AAH20695 BC058010 AAH58010 BC140943 AAI40944 BJ995129 BP244862 BX537776 BX640601 CAE45707 CN367875 D90282 BAA14328 DA804480 DC402554 Y15793 CAA75785 XM_011510640 XP_011508942 XM_011510641 XP_011508943 XM_011510642 XP_011508944 XM_011510643 XP_011508945 XM_011510644 XP_011508946 NM_001122633 NP_001116105 NM_001122634 NP_001116106 NM_001875 NP_001866
Function Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}.
Tissue Specificity Primarily in the liver and small intestine.
Top Pathways Nitrogen metabolism, Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism, Biosynthesis of amino acids, Carbon metabolism

CPS1 (B-1) - sc-376190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CPS1 (B-1): sc-376190. Immunofluorescence staining of methanol-fixed HeLa cells showing mitochondrial localization.

CPS1 (E-20) - sc-10516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CPS1 (E-20): sc-10516. Western blot analysis of CPS1 expression in mouse liver tissue extract.

CPS1 (N-18) - sc-10515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CPS1 (N-18): sc-10515. Western blot analysis of CPS1 expression in rat brain tissue extract.

CPS1 (H-140) - sc-30060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CPS1 (H-140): sc-30060. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

Anti-CPS1 antibody - ab54586 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
CPS1 antibody (ab54586) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-CPS1 antibody - ab123859 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CPS1 antibody (ab123859) at 1/100 dilution + Hela cell line lysate at 35 µg

Anti-CPS1 antibody [2E4AE11] - ab110303 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4AE11
Immunocytochemistry analysis using ab110303 at 10µg/ml staining CPS1 in HDFn cells (paraformaldehyde fixed and Triton X-100 permeabilized). The secondary antibody was (red) Alexa Fluor® 594 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. 10% Goat serum was used as the blocking agent for all blocking steps. DAPI was used to stain the cell nuclei (blue). Target protein locates mainly in mitochondria.

Anti-CPS1 antibody [8H8] - ab117467 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 8H8
ab117467, at 5&microg/ml, staining CPS1 in formalin-fixed, paraffin-embedded Human liver tissue by immunohistochemistry.

Anti-CPS1 antibody [EPR7493] - ab129076 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7493
All lanes : Anti-CPS1 antibody [EPR7493] (ab129076) at 1/1000 dilutionLane 1 : Fetal liver cell lysateLane 2 : Mouse liver cell lysateLane 3 : Rat liver cell lysateLane 4 : HeLa cell lysate

Anti-CPS1 antibody [EPR7493] - ab155083 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7493
All lanes : Anti-CPS1 antibody [EPR7493] (ab155083) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal liver lysateLane 3 : Rat liver lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-CPS1 antibody [EPR7494] - ab128942 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7494
All lanes : Anti-CPS1 antibody [EPR7494] (ab128942) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal liver tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CPS1 antibody - Liver Mitochondrial Marker - ab45956 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CPS1 antibody - Liver Mitochondrial Marker (ab45956) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-CPS1 Antibody (Internal, clone EPR7493) IHC-plus™ - LS-B9369 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR7493
Anti-CPS1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CPS1 Antibody (C-Terminus) - LS-C203219 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291, AP) - LS-C255360 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291, APC) - LS-C255361 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291, Biotin) - LS-C255362 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291, FITC) - LS-C255363 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa151-200) - LS-C80753 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CPS1 antibody LS-C80753 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-CPS1 Antibody (aa951-1000) - LS-C80754 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CPS1 antibody LS-C80754 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-CPS1 Antibody (aa261-291, Azide-free, HRP) - LS-C255364 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291, PE) - LS-C255365 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPS1 Antibody (aa261-291) - LS-C167002 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CPS1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The CPS1 antibody detected the CPS1 protein (arrow).

Anti-CPS1 Antibody (aa1400-1501, Azide-free) - LS-C327003 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CPS1 Antibody (aa261-291) - LS-C320566 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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