Gene Symbol | CPS1 |
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Entrez Gene | 1373 |
Alt Symbol | CPSASE1, PHN |
Species | Human |
Gene Type | protein-coding |
Description | carbamoyl-phosphate synthase 1, mitochondrial |
Other Description | carbamoyl-phosphate synthase [ammonia], mitochondrial|carbamoylphosphate synthetase I |
Swissprots | P31327 O43774 J3KQL0 B7Z818 Q7Z5I5 Q59HF8 Q53TL5 |
Accessions | AAN77181 AAO31763 AAY14960 CAL39127 CCA94564 CCD32697 CCD32852 EAW70492 EAW70493 EAW70494 P31327 AB180933 BAD74204 AB180934 BAD74205 AB180935 BAD74206 AB180936 BAD74207 AB180937 BAD74208 AB180938 BAD74209 AB208800 BAD92037 AF154830 AAD38072 AK289749 BAF82438 AK302778 BAH13804 AK316425 BAH14796 AL704546 AV645723 AY317138 AAP84318 BC020695 AAH20695 BC058010 AAH58010 BC140943 AAI40944 BJ995129 BP244862 BX537776 BX640601 CAE45707 CN367875 D90282 BAA14328 DA804480 DC402554 Y15793 CAA75785 XM_011510640 XP_011508942 XM_011510641 XP_011508943 XM_011510642 XP_011508944 XM_011510643 XP_011508945 XM_011510644 XP_011508946 NM_001122633 NP_001116105 NM_001122634 NP_001116106 NM_001875 NP_001866 |
Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. |
Tissue Specificity | Primarily in the liver and small intestine. |
Top Pathways | Nitrogen metabolism, Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism, Biosynthesis of amino acids, Carbon metabolism |
CPS1 CRISPR/Cas9 KO Plasmid (h) - sc-402014 from Santa Cruz Biotechnology
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CPS1 HDR Plasmid (h) - sc-402014-HDR from Santa Cruz Biotechnology
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CPS1 Double Nickase Plasmid (h) - sc-402014-NIC from Santa Cruz Biotechnology
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CPS1 Double Nickase Plasmid (h2) - sc-402014-NIC-2 from Santa Cruz Biotechnology
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CPS1 CRISPR Activation Plasmid (h) - sc-402014-ACT from Santa Cruz Biotechnology
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CPS1 CRISPR Activation Plasmid (h2) - sc-402014-ACT-2 from Santa Cruz Biotechnology
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CPS1 Lentiviral Activation Particles (h) - sc-402014-LAC from Santa Cruz Biotechnology
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CPS1 Lentiviral Activation Particles (h2) - sc-402014-LAC-2 from Santa Cruz Biotechnology
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CPS1 siRNA (h) - sc-35099 from Santa Cruz Biotechnology
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CPS1 shRNA Plasmid (h) - sc-35099-SH from Santa Cruz Biotechnology
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CPS1 shRNA (h) Lentiviral Particles - sc-35099-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU002511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6520 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6520 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08057 from Sigma-Aldrich
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CPS1 siRNA (Human) - CRH0961 from Cohesion Biosciences
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CPS1 RNAi - H00001373-R01 from Novus Biologicals
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CPS1 - MBS8201789 from MyBioSource
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shRNA set against Human CPS1 (NM_001875.4) - SHH268897 from Creative biogene
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CPS1 CRISPR/Cas9 KO Plasmid (h2) - sc-402014-KO-2 from Santa Cruz Biotechnology
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CPS1 HDR Plasmid (h2) - sc-402014-HDR-2 from Santa Cruz Biotechnology
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CPS1 shRNA Plasmid (Human) - CHH0961 from Cohesion Biosciences
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CPS1 miRNA 3'UTR clone - MiUTR3H-09905 from Creative biogene
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CPS1 miRNA 3'UTR clone - MiUTR3H-09906 from Creative biogene
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CPS1 miRNA 3'UTR clone - MiUTR3H-09907 from Creative biogene
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