Gene Symbol |
FBXL12
|
Entrez Gene |
54850
|
Alt Symbol |
Fbl12
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
F-box and leucine-rich repeat protein 12
|
Other Description |
F-box protein FBL12|F-box/LRR-repeat protein 12
|
Swissprots |
B3KSJ8 Q9H5K4 Q9NXK8
|
Accessions |
EAW84051 EAW84052 EAW84053 Q9NXK8 AK000195 BAA91002 AK027004 BAB15622 AK093760 BAG52760 AL389936 BC001586 AAH01586 BX647073 HQ447834 ADQ32318 XM_005259964 XP_005260021 XM_005259965 XP_005260022 XM_005259966 XP_005260023 XM_006722782 XP_006722845 XM_011528109 XP_011526411 XM_011528110 XP_011526412 NM_017703 NP_060173
|
Function |
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269|PubMed:23707388}.
|