Gene Symbol | FBXL12 |
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Entrez Gene | 54850 |
Alt Symbol | Fbl12 |
Species | Human |
Gene Type | protein-coding |
Description | F-box and leucine-rich repeat protein 12 |
Other Description | F-box protein FBL12|F-box/LRR-repeat protein 12 |
Swissprots | B3KSJ8 Q9H5K4 Q9NXK8 |
Accessions | EAW84051 EAW84052 EAW84053 Q9NXK8 AK000195 BAA91002 AK027004 BAB15622 AK093760 BAG52760 AL389936 BC001586 AAH01586 BX647073 HQ447834 ADQ32318 XM_005259964 XP_005260021 XM_005259965 XP_005260022 XM_005259966 XP_005260023 XM_006722782 XP_006722845 XM_011528109 XP_011526411 XM_011528110 XP_011526412 NM_017703 NP_060173 |
Function | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269|PubMed:23707388}. |
FBL12 CRISPR/Cas9 KO Plasmid (h) - sc-412350 from Santa Cruz Biotechnology
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FBL12 HDR Plasmid (h) - sc-412350-HDR from Santa Cruz Biotechnology
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FBL12 Double Nickase Plasmid (h) - sc-412350-NIC from Santa Cruz Biotechnology
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FBL12 Double Nickase Plasmid (h2) - sc-412350-NIC-2 from Santa Cruz Biotechnology
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FBL12 CRISPR Activation Plasmid (h) - sc-412350-ACT from Santa Cruz Biotechnology
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FBL12 CRISPR Activation Plasmid (h2) - sc-412350-ACT-2 from Santa Cruz Biotechnology
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FBL12 Lentiviral Activation Particles (h) - sc-412350-LAC from Santa Cruz Biotechnology
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FBL12 Lentiviral Activation Particles (h2) - sc-412350-LAC-2 from Santa Cruz Biotechnology
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FBL12 siRNA (h) - sc-97389 from Santa Cruz Biotechnology
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FBL12 shRNA Plasmid (h) - sc-97389-SH from Santa Cruz Biotechnology
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FBL12 shRNA (h) Lentiviral Particles - sc-97389-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8514 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05581 from Sigma-Aldrich
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FBXL12 siRNA (Human) - CRJ0264 from Cohesion Biosciences
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FBXL12 - MBS8239585 from MyBioSource
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shRNA set against Human FBXL12 (NM_017703.1) - SHH292813 from Creative biogene
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shRNA set against Human FBXL12(NM_017703.1) - SHH050807 from Creative biogene
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FBXL12 shRNA Plasmid (Human) - CHJ0264 from Cohesion Biosciences
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FBXL12 miRNA 3'UTR clone - MiUTR1H-03539 from Creative biogene
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