Gene Symbol | Nobox |
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Entrez Gene | 18291 |
Alt Symbol | OG2, Og2x |
Species | Mouse |
Gene Type | protein-coding |
Description | NOBOX oogenesis homeobox |
Other Description | OG2 homeobox|homeobox protein NOBOX|homeodomain-containing protein OG-2|newborn ovary homeobox protein|oocyte-specific homeobox protein |
Swissprots | P70367 Q8VIH1 |
Accessions | AAC52828 EDL13447 Q8VIH1 AB221582 AY061761 AAL29683 BC125280 AAI25281 BC125282 AAI25283 XM_006505717 XP_006505780 XM_006505719 XP_006505782 NM_130869 NP_570939 |
Function | Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis. {ECO:0000269|PubMed:15326356, ECO:0000269|PubMed:16997917}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Specifically expressed in ovaries and testes. In ovaries, expressed in oocytes from primordial through antral follicles but not in granulosa cells, theca cells and corpora lutea. {ECO:0000269|PubMed:11804785}. |
NOBOX CRISPR/Cas9 KO Plasmid (m) - sc-422009 from Santa Cruz Biotechnology
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NOBOX HDR Plasmid (m) - sc-422009-HDR from Santa Cruz Biotechnology
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NOBOX Double Nickase Plasmid (m) - sc-422009-NIC from Santa Cruz Biotechnology
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NOBOX Double Nickase Plasmid (m2) - sc-422009-NIC-2 from Santa Cruz Biotechnology
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NOBOX CRISPR Activation Plasmid (m) - sc-422009-ACT from Santa Cruz Biotechnology
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NOBOX CRISPR Activation Plasmid (m2) - sc-422009-ACT-2 from Santa Cruz Biotechnology
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NOBOX Lentiviral Activation Particles (m) - sc-422009-LAC from Santa Cruz Biotechnology
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NOBOX Lentiviral Activation Particles (m2) - sc-422009-LAC-2 from Santa Cruz Biotechnology
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NOBOX siRNA (m) - sc-150015 from Santa Cruz Biotechnology
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NOBOX shRNA Plasmid (m) - sc-150015-SH from Santa Cruz Biotechnology
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NOBOX shRNA (m) Lentiviral Particles - sc-150015-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36548 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36548 from Sigma-Aldrich
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NOBOX siRNA (Mouse) - CRM2883 from Cohesion Biosciences
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shRNA set against Mouse Nobox (NM_130869.3) - SHH353396 from Creative biogene
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NOBOX shRNA Plasmid (Mouse) - CHM2883 from Cohesion Biosciences
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NOBOX miRNA 3'UTR clone - MiUTR1M-07723 from Creative biogene
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