EGLN1

Gene Symbol	EGLN1
Entrez Gene	54583
Alt Symbol	C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6
Species	Human
Gene Type	protein-coding
Description	egl-9 family hypoxia-inducible factor 1
Other Description	HIF prolyl hydroxylase 2|HIF-prolyl hydroxylase 2|egl nine homolog 1|egl nine-like protein 1|hypoxia-inducible factor prolyl hydroxylase 2|prolyl hydroxylase domain-containing protein 2|zinc finger MYND domain-containing protein 6
Swissprots	Q9BZS8 Q9GZT9 Q8N3M8 Q9BZT0
Accessions	AAG34568 AFM52328 AGL94896 AGL94897 AGL94898 AGL94899 AGL94900 AGL94901 AGL94902 AGL94903 AGL94904 AGL94905 AGL94906 AGL94907 AGL94908 AGL94909 AGL94910 AGL94911 AGL94912 AGL94913 AGL94914 AGL94915 AGL94916 AGL94917 AGL94918 AGL94919 AGL94920 AGL94921 AGL94922 AGL94923 AGL94924 AGL94925 AGL94926 AGL94927 AGL94928 AGL94929 AGL94930 AGL94931 AGL94932 AGL94933 AGL94934 AGL94935 AGL94936 AGL94937 AGL94938 AGL94939 AGL94940 AGL94941 CAP11376 CDM55390 CDM55571 EAW69959 Q9GZT9 AF229245 AAG33965 AF277174 AAK07534 AF277176 AAK07536 AF334711 AI017372 AJ227859 AJ310543 CAC42509 AL833885 CAD38741 BC005369 AAH05369 DQ975380 ABM44413 XM_005273166 XP_005273223 XM_005273167 XP_005273224 NM_022051 NP_071334
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recogniz
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Nucleus {ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm (PubMed:19631610). Nuclear export requires functional XPO1. {ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Tissue Specificity	According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle. {ECO:0000269|PubMed:11056053, ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:12670503, ECO:0000269|PubMed:12788921}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse EGLN1 / PHD2 ELISA Kit (Sandwich ELISA) - LS-F8436 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.116 ng/ml Range 0.313-20 ng/ml

Human EGLN1 / PHD2 ELISA Kit (Sandwich ELISA) - LS-F9924 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 13.2 pg/ml Range 0.313-20 ng/ml

Human Egl Nine Homolog 1 ELISA Kit - abx151386 from Abbexa Category ELISA Kit Sensitivity 13.2 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Egl nine homolog 1 (EGLN1/C1orf12/PNAS-118/PNAS-137), Human, ELISA Kit - CSB-E17313h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Egl Nine Homolog 1, ELISA Kit - MBS070147 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS097037 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS080171 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS084275 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS085591 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS100745 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Egl Nine Homolog 1, ELISA Kit - MBS086480 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

egl nine homolog 1 (C. elegans) , ELISA Kit - MBS916867 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human EGLN1/C1ORF12/PNAS-118/PNAS-137 is typically less than 7.8 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

Egl Nine Homolog 1 (EGLN1), ELISA Kit - MBS2024466 from MyBioSource Category ELISA Kit Prices $420.00, $625.00, $855.00, $3,510.00, $6,365.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of EGLN1 is typically less than 0.116ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

Egl Nine Homolog 1 (EGLN1), ELISA Kit - MBS2024781 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 13.2pg/mL. Range 31.25-2000pg/mL

ELISA Kit for Egl Nine Homolog 1 (EGLN1) - SEL644Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.2pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

ELISA Kit for Egl Nine Homolog 1 (EGLN1) - SEL644Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.108ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Egl nine homolog 1 (EGLN1/C1orf12/PNAS-118/PNAS-137) ELISA kit - CSB-E17313h from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

ELISA Kit for Egl Nine Homolog 1 (EGLN1) - SEL644Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.2pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human Egl Nine Homolog 1 (EGLN1) ELISA Kit - EKU03836 from Biomatik Category ELISA Kit Prices $809.00, $3,557.00, $6,468.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 13.5 pg/mL Range 31.25-2000 pg/mL

Human Egl nine homolog 1 (EGLN1/C1orf12/PNAS-118/PNAS-137) ELISA Kit - EKC33544 from Biomatik Category ELISA Kit Prices $795.00, $3,021.00, $5,644.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

Human EGLN1 ELISA Kit - E012831 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human EGLN1/C1ORF12/PNAS-118/PNAS-137 is typically less than 7.8 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero.

EGLN1 ELISA Kit (Human) (OKCD02054) - OKCD02054 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 13.5 pg/mL Range 31.2 - 2,000 pg/mL

anti-EGLN1 / PHD2 antibody [1E9] - ARG56992 from Arigo Biolaboratories Category ELISA Kit

Human Egl nine homolog 1 (EGLN1) ELISA Kit - AE46022HU from ARP American Research Products Category ELISA Kit Prices $612.00 Sizes 96 t Sensitivity 13.5 pg/mL Range 31.25-2000 pg/mL

Egl Nine Homolog 1 (EGLN1), ELISA Kit - MBS9378128 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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