Gene Symbol | P2RY2 |
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Entrez Gene | 5029 |
Alt Symbol | HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R |
Species | Human |
Gene Type | protein-coding |
Description | purinergic receptor P2Y, G-protein coupled, 2 |
Other Description | ATP receptor|P2U nucleotide receptor|P2U purinoceptor 1|P2U receptor 1|P2Y purinoceptor 2|purinergic receptor P2Y2|purinoceptor P2Y2 |
Swissprots | B2R9W3 Q96EM8 P41231 |
Accessions | EAW74882 EAW74883 EAW74884 P41231 AK094727 AK313942 BAG36660 AY136753 AAN01279 BC012104 AAH12104 BC028135 AAH28135 BX641058 DQ892258 ABM83184 DQ895460 ABM86386 FJ599699 ACS66693 FJ599700 ACS66694 HG503966 U07225 AAC04923 XM_005274019 XP_005274076 XM_005274020 XP_005274077 XM_005274021 XP_005274078 XM_011545074 XP_011543376 NM_002564 NP_002555 NM_176071 NP_788085 NM_176072 NP_788086 |
Function | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Spleen, testis, kidney, liver, lung, heart and brain. |
Top Pathways | Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
P2Y2 CRISPR/Cas9 KO Plasmid (h) - sc-401303 from Santa Cruz Biotechnology
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P2Y2 HDR Plasmid (h) - sc-401303-HDR from Santa Cruz Biotechnology
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P2Y2 Double Nickase Plasmid (h) - sc-401303-NIC from Santa Cruz Biotechnology
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P2Y2 Double Nickase Plasmid (h2) - sc-401303-NIC-2 from Santa Cruz Biotechnology
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P2Y2 CRISPR Activation Plasmid (h) - sc-401303-ACT from Santa Cruz Biotechnology
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P2Y2 CRISPR Activation Plasmid (h2) - sc-401303-ACT-2 from Santa Cruz Biotechnology
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P2Y2 Lentiviral Activation Particles (h) - sc-401303-LAC from Santa Cruz Biotechnology
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P2Y2 Lentiviral Activation Particles (h2) - sc-401303-LAC-2 from Santa Cruz Biotechnology
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P2Y2 siRNA (h) - sc-42579 from Santa Cruz Biotechnology
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P2Y2 shRNA Plasmid (h) - sc-42579-SH from Santa Cruz Biotechnology
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P2Y2 shRNA (h) Lentiviral Particles - sc-42579-V from Santa Cruz Biotechnology
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P2Y2 RNAi - H00005029-R05 from Novus Biologicals
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P2Y2 RNAi - H00005029-R04 from Novus Biologicals
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MISSION® esiRNA - EHU156731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16236 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16236 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07754 from Sigma-Aldrich
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P2RY2 siRNA (Human) - CRH3342 from Cohesion Biosciences
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P2Y2 RNAi - H00005029-R06 from Novus Biologicals
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shRNA set against Human P2RY2 (NM_002564.2) - SHH369588 from Creative biogene
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shRNA set against Human P2RY2(NM_002564.2) - SHR085296 from Creative biogene
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Human P2RY2 siRNA - orb263844 from Biorbyt
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P2RY2 shRNA Plasmid (Human) - CHH3342 from Cohesion Biosciences
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P2RY2 miRNA 3'UTR clone - MiUTR1H-07446 from Creative biogene
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P2RY2 miRNA 3'UTR clone - MiUTR3H-03102 from Creative biogene
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