Gene Symbol | CALR |
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Entrez Gene | 281036 |
Alt Symbol | - |
Species | Bovine |
Gene Type | protein-coding |
Description | calreticulin |
Other Description | CRP55|HACBP|calrectulin|calregulin |
Swissprots | P28489 Q8SQ53 P42918 P52193 |
Accessions | DAA28020 P52193 AB067687 BAB86913 BC140582 AAI40583 L13462 AAC37307 NM_174000 NP_776425 |
Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12782144}. Sarcoplasmic reticulum lumen {ECO:0000250}. |
Top Pathways | Chagas disease (American trypanosomiasis), Phagosome, Protein processing in endoplasmic reticulum, HTLV-I infection, Antigen processing and presentation |
SS-A (Ro) Antigen - MD-27-0016P from RayBiotech
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Recombinant Bovine Calreticulin(CALR) - CSB-YP004458BO CSB-EP004458BO CSB-BP004458BO CSB-MP004458BO from Cusabio
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Calreticulin (CALR), Recombinant Protein - MBS948662 from MyBioSource
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