PRKCG

Gene Symbol	PRKCG
Entrez Gene	5582
Alt Symbol	PKC-gamma, PKCC, PKCG, SCA14
Species	Human
Gene Type	protein-coding
Description	protein kinase C, gamma
Other Description	protein kinase C gamma type
Swissprots	B7Z8Q0 P05129
Accessions	CAA44394 EAW72161 P05129 AB209671 BAD92908 AF345987 AAK13533 AK296412 BAH12345 AK296434 BAH12352 AK302958 BAH13856 AK303741 BAH14036 AK312302 BAG35228 BC047876 AAH47876 BI757265 M13977 AAA60102 Z15114 CAA78820 XM_011527107 XP_011525409 XM_011527108 XP_011525410 NM_002739 NP_002730
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P63318}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}.
Tissue Specificity	Expressed in Purkinje cells of the cerebellar cortex. {ECO:0000269|PubMed:12644968}.
Top Pathways	Thyroid hormone synthesis, Proteoglycans in cancer, Amphetamine addiction, Sphingolipid signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKCG - MBS1270450 from MyBioSource Species Human Accession BC047876

Human PRKCG cDNA clone(NM_002739.3) - CDFH015123 from Creative Biomart Species Human Accession NM_002739.3

Human PRKCG cDNA clone(NM_002739.3) - CDFH015124 from Creative Biomart Species Human Accession NM_002739.3

Human PRKCG ORF Clone(NM_002739.3) - CDCR283934 from Creative Biomart Species Human Accession NM_002739.3

Human PRKCG ORF Clone(NM_002739.3) - CDCR283956 from Creative Biomart Species Human Accession NM_002739.3

Human PRKCG ORF clone(NM_002739.3) - CDCL185828 from Creative Biomart Species Human Accession NM_002739.3

Human PRKCG/PKCG Gene ORF cDNA clone in cloning vector - HG11242-M from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-HA tag - HG11242-CY from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid - HG11242-UT from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11242-ACR from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11242-ANR from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11242-M-F from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11242-NF from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11242-NM from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11242-ANG from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11242-CF from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-HA tag - HG11242-NY from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11242-CM from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, N-His tag - HG11242-NH from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-His tag - HG11242-CH from Sino Biological Species Human

Human PRKCG/PKCG Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11242-ACG from Sino Biological Species Human

Human PRKCG ORF clone(NM_002739.3) - CDCL185828 from Creative biogene Species Human

Human PRKCG ORF Clone (BC047876) - CDCS410931 from Creative biogene Species Human Accession P05129

Human PRKCG gene - orb91786 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human PRKCG cDNA Clone(NM_002739.3) - CDFH015123 from Creative biogene Species Human

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