PRKCG

Gene Symbol	PRKCG
Entrez Gene	5582
Alt Symbol	PKC-gamma, PKCC, PKCG, SCA14
Species	Human
Gene Type	protein-coding
Description	protein kinase C, gamma
Other Description	protein kinase C gamma type
Swissprots	B7Z8Q0 P05129
Accessions	CAA44394 EAW72161 P05129 AB209671 BAD92908 AF345987 AAK13533 AK296412 BAH12345 AK296434 BAH12352 AK302958 BAH13856 AK303741 BAH14036 AK312302 BAG35228 BC047876 AAH47876 BI757265 M13977 AAA60102 Z15114 CAA78820 XM_011527107 XP_011525409 XM_011527108 XP_011525410 NM_002739 NP_002730
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P63318}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}.
Tissue Specificity	Expressed in Purkinje cells of the cerebellar cortex. {ECO:0000269|PubMed:12644968}.
Top Pathways	Thyroid hormone synthesis, Proteoglycans in cancer, Amphetamine addiction, Sphingolipid signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC gamma full length protein - ab60842 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC gamma protein fragment - ab159201 from Abcam Category Protein Source Wheat germ Species Human

PRKCG / PKC-Gamma Antibody Blocking Peptide - LS-E3509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCG / PKC-Gamma Antibody Blocking Peptide - LS-E20481 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCG / PKC-Gamma Antibody Blocking Peptide - LS-E20482 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCG / PKC-Gamma Antibody Blocking Peptide - LS-E8611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKC gamma Partial Recombinant Protein - H00005582-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKC gamma Recombinant Protein - P4245 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human PKC gamma Protein - P4759 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant PKC gamma Protein - NBP1-99473 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKC gamma Peptide - P2108 from Novus Biologicals Category Peptide Species Human

PKC-gamma-Antibody-C-term-Blocking-Peptide - BP7021a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKCG-Antibody-N-term-Blocking-Peptide - BP8574a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKCG Blocking Peptide - 33R-3124 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKCG Blocking Peptide - 33R-10011 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKCG - H00005582-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCG - H00005582-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCG - P4245 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKCG - P4759 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Glycogen synthase kinase-3 beta, Human Recombinant - 228-11259-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human PKC gamma [+His] [from Sf9] - 228-11259-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human PKC gamma [+His] [from Sf9] - 228-11259-3 from RayBiotech Category Protein Prices $5,203.00 Sizes 3 µg Source Sf9 insect cells. Species Human

PRKCG fusion protein - ag0892 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PRKCG fusion protein - ag5681 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PRKCG fusion protein - Ag5910 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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