Gene Symbol | RHOC |
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Entrez Gene | 389 |
Alt Symbol | ARH9, ARHC, H9, RHOH9 |
Species | Human |
Gene Type | protein-coding |
Description | ras homolog family member C |
Other Description | RAS-related homolog 9|oncogene RHO H9|ras homolog gene family, member C|rho cDNA clone 9|rho-related GTP-binding protein RhoC|rhoC GTPase|small GTP binding protein RhoC |
Swissprots | Q6ICN3 P08134 B3KSW1 |
Accessions | CAI61764 EAW56533 EAW56534 EAW56535 EAW56536 EAW56539 P08134 AF085893 AF498972 AAM21119 AK094474 BAG52873 BC007245 AAH07245 BC009177 AAH09177 BC052808 AAH52808 BQ231012 BT019448 AAV38255 BX648784 CA307508 CB851337 CN289691 CR450360 CAG29356 CX872299 DQ893171 ABM84097 DQ896470 ABM87469 L25081 AAC33179 X06821 CAA29969 NM_001042678 NP_001036143 NM_001042679 NP_001036144 NM_175744 NP_786886 |
Function | Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000269|PubMed:16236794}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. |
Rho C CRISPR/Cas9 KO Plasmid (h) - sc-401242 from Santa Cruz Biotechnology
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Rho C HDR Plasmid (h) - sc-401242-HDR from Santa Cruz Biotechnology
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Rho C Double Nickase Plasmid (h) - sc-401242-NIC from Santa Cruz Biotechnology
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Rho C Double Nickase Plasmid (h2) - sc-401242-NIC-2 from Santa Cruz Biotechnology
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Rho C CRISPR Activation Plasmid (h) - sc-401242-ACT from Santa Cruz Biotechnology
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Rho C CRISPR Activation Plasmid (h2) - sc-401242-ACT-2 from Santa Cruz Biotechnology
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Rho C Lentiviral Activation Particles (h) - sc-401242-LAC from Santa Cruz Biotechnology
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Rho C Lentiviral Activation Particles (h2) - sc-401242-LAC-2 from Santa Cruz Biotechnology
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Rho C siRNA (h) - sc-41887 from Santa Cruz Biotechnology
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Rho C shRNA Plasmid (h) - sc-41887-SH from Santa Cruz Biotechnology
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Rho C shRNA (h) Lentiviral Particles - sc-41887-V from Santa Cruz Biotechnology
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RhoC RNAi - H00000389-R01 from Novus Biologicals
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MISSION® esiRNA - EHU065971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18254 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18254 from Sigma-Aldrich
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RHOC siRNA (Human) - CRH0278 from Cohesion Biosciences
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RHOC - MBS8227396 from MyBioSource
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shRNA set against Human Rhoc (NM_175744.4) - SHH395324 from Creative biogene
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shRNA set against Human RHOC(NM_001042678.1) - SHR180960 from Creative biogene
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Human RHOC siRNA - orb260780 from Biorbyt
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RHOC shRNA Plasmid (Human) - CHH0278 from Cohesion Biosciences
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RHOC miRNA 3'UTR clone - MiUTR1H-08812 from Creative biogene
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RHOC miRNA 3'UTR clone - MiUTR3H-01646 from Creative biogene
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RHOC miRNA 3'UTR clone - MiUTR3H-01647 from Creative biogene
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