| Gene Symbol | BSG |
|---|---|
| Entrez Gene | 682 |
| Alt Symbol | 5F7, CD147, EMMPRIN, M6, OK, TCSF |
| Species | Human |
| Gene Type | protein-coding |
| Description | basigin (Ok blood group) |
| Other Description | CD147 antigen|OK blood group antigen|basigin|collagenase stimulatory factor|extracellular matrix metalloproteinase inducer|leukocyte activation antigen M6|tumor cell-derived collagenase stimulatory factor |
| Swissprots | Q7Z796 A6NJW1 Q8IZL7 D3YLG5 P35613 |
| Accessions | AAC33279 AAD10704 AAX20110 EAW61180 EAW61181 EAW61182 EAW61183 EAW61184 EAW61185 EAW61186 EAW61187 P35613 AB072923 BAB88938 AB085790 BAC76828 AB091680 BAC67168 AF548371 AAN40694 AK095912 AK296858 BAG59422 AK297880 BAG60203 AK302231 BAG63585 AY358113 AAQ88480 BC009040 AAH09040 BG480530 BI464857 BU501595 CB153773 D28441 BAA05807 D45131 BAA08109 DA007913 GU557064 ADD31881 GU557065 ADD31882 JF432780 ADZ15997 L10240 AAA68936 L20471 AAB41120 M87879 AAA91084 X64364 CAA45716 XM_005259619 XP_005259676 NM_001728 NP_001719 NM_198589 NP_940991 NM_198590 NP_940992 NM_198591 NP_940993 |
| Function | Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269|PubMed:17127621}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15946952}; Single-pass type I membrane protein {ECO:0000303|PubMed:15946952}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:17081065}. |
| Tissue Specificity | Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas. |
EMMPRIN CRISPR/Cas9 KO Plasmid (h) - sc-400589 from Santa Cruz Biotechnology
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EMMPRIN HDR Plasmid (h) - sc-400589-HDR from Santa Cruz Biotechnology
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EMMPRIN Double Nickase Plasmid (h) - sc-400589-NIC from Santa Cruz Biotechnology
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EMMPRIN Double Nickase Plasmid (h2) - sc-400589-NIC-2 from Santa Cruz Biotechnology
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EMMPRIN CRISPR Activation Plasmid (h) - sc-400589-ACT from Santa Cruz Biotechnology
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EMMPRIN CRISPR Activation Plasmid (h2) - sc-400589-ACT-2 from Santa Cruz Biotechnology
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EMMPRIN Lentiviral Activation Particles (h) - sc-400589-LAC from Santa Cruz Biotechnology
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EMMPRIN Lentiviral Activation Particles (h2) - sc-400589-LAC-2 from Santa Cruz Biotechnology
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EMMPRIN siRNA (h) - sc-35298 from Santa Cruz Biotechnology
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EMMPRIN shRNA Plasmid (h) - sc-35298-SH from Santa Cruz Biotechnology
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EMMPRIN shRNA (h) Lentiviral Particles - sc-35298-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1227 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1227 from Sigma-Aldrich
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BSG siRNA (Human) - CRH0474 from Cohesion Biosciences
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BSG - MBS8203042 from MyBioSource
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shRNA set against Human BSG (NM_001728.3) - SHH247954 from Creative biogene
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Human BSG siRNA - orb260976 from Biorbyt
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BSG shRNA Plasmid (Human) - CHH0474 from Cohesion Biosciences
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BSG miRNA 3'UTR clone - MiUTR3H-00242 from Creative biogene
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BSG miRNA 3'UTR clone - MiUTR3H-00243 from Creative biogene
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BSG miRNA 3'UTR clone - MiUTR3H-00244 from Creative biogene
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