RPE65

Gene Symbol RPE65
Entrez Gene 6121
Alt Symbol BCO3, LCA2, RP20, mRPE65, rd12, sRPE65
Species Human
Gene Type protein-coding
Description retinal pigment epithelium-specific protein 65kDa
Other Description BCO family, member 3|RBP-binding membrane protein|all-trans-retinyl-palmitate hydrolase|p63|retinal pigment epithelium-specific 65 kDa protein|retinitis pigmentosa 20 (autosomal recessive)|retinoid isomerohydrolase|retinol isomerase
Swissprots A8K1L0 Q16518 Q5T9U3
Accessions AAC14586 AAC39660 ABD37636 ACT83679 AFF57192 CCQ42977 EAX06478 Q16518 AK289925 BAF82614 BC075035 AAH75035 BC075036 AAH75036 U18991 AAA99012 NM_000329 NP_000320
Function Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association. {ECO:0000269|PubMed:16116091, ECO:0000269|PubMed:21654732}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Microsome membrane {ECO:0000250}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity). Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. {ECO:0000250, ECO:0000269|PubMed:21493626}.
Tissue Specificity Retinal pigment epithelium specific. {ECO:0000269|PubMed:21493626}.
Top Pathways Retinol metabolism

Retinoid isomerohydrolase (RPE65), Human, ELISA Kit - E01R0420 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Chicken RPE65 ELISA Kit (Custom ELISA) - LS-F20582 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Bovine RPE65 ELISA Kit (Custom ELISA) - LS-F20577 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Dog RPE65 ELISA Kit (Custom ELISA) - LS-F20578 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Rat RPE65 ELISA Kit (Custom ELISA) - LS-F20579 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Human RPE65 ELISA Kit (Custom ELISA) - LS-F20581 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Mouse RPE65 ELISA Kit (Custom ELISA) - LS-F20580 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Human Retinoid isomerohydrolase ELISA Kit - abx251887 from Abbexa

Category ELISA Kit
Range 78 pg/ml - 5000 pg/ml

Human Retinoid isomerohydrolase ELISA Kit - EKE54298 from Biomatik

Category ELISA Kit
Prices $759.00, $3,226.00, $6,072.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 32 pg/mL
Range 78-5000 pg/mL

RPE65 - EKH5032 from Nordic BioSite

Sensitivity 46.9pg/ml
Range 78-5000pg/ml

RPE65 ELISA Kit (Human) (OKEH02018) - OKEH02018 from Aviva Systems Biology

Category ELISA Kit
Prices $450.00
Sizes 96 wells
Sensitivity < 32 pg/mL
Range 78 - 5,000 pg/mL

Human RPE65 ELISA Kit - E033378 from Biobool

Category ELISA Kit
Sensitivity 0.1 ng/mL.

Human Retinoid isomerohydrolase ELISA Kit - EK5049 from Signalway Antibody

Category ELISA Kit
Prices $659.00
Sizes 1x96t
Sensitivity less than 32pg/mL
Range 78-5000 pg/mL

anti-RPE65 antibody - ARG64436 from Arigo Biolaboratories

Category ELISA Kit

Retinoid isomerohydrolase, ELISA Kit - MBS9428875 from MyBioSource

Category ELISA Kit
Prices $605.00
Sizes 96 tests
Sensitivity Less than 32pg/mL
Range 78-5000 pg/mL

Retinoid isomerohydrolase, ELISA Kit - MBS2887655 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 78-5000 pg/mL

Human RPE65 ELISA Kit (Sandwich ELISA) - LS-F33641 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 46.9
Range 78 - 5000 pg/ml
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