RPE65

Gene Symbol RPE65
Entrez Gene 6121
Alt Symbol BCO3, LCA2, RP20, mRPE65, rd12, sRPE65
Species Human
Gene Type protein-coding
Description retinal pigment epithelium-specific protein 65kDa
Other Description BCO family, member 3|RBP-binding membrane protein|all-trans-retinyl-palmitate hydrolase|p63|retinal pigment epithelium-specific 65 kDa protein|retinitis pigmentosa 20 (autosomal recessive)|retinoid isomerohydrolase|retinol isomerase
Swissprots A8K1L0 Q16518 Q5T9U3
Accessions AAC14586 AAC39660 ABD37636 ACT83679 AFF57192 CCQ42977 EAX06478 Q16518 AK289925 BAF82614 BC075035 AAH75035 BC075036 AAH75036 U18991 AAA99012 NM_000329 NP_000320
Function Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association. {ECO:0000269|PubMed:16116091, ECO:0000269|PubMed:21654732}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Microsome membrane {ECO:0000250}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity). Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. {ECO:0000250, ECO:0000269|PubMed:21493626}.
Tissue Specificity Retinal pigment epithelium specific. {ECO:0000269|PubMed:21493626}.
Top Pathways Retinol metabolism

Human RPE65 peptide - ab99880 from Abcam

Category Peptide
Species Human

RPE65 Antibody Blocking Peptide - LS-E26633 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

RPE65 blocking peptide - GTX88833-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Dog, Rat

RPE65 Peptide - AC21-1469-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

RPE65 Peptide - 46-321P from ProSci

Category Peptide
Species Rat

RPE65 fusion protein - Ag12617 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

RPE65 fusion protein - ag12356 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human RPE65, His-tagged - RPE65-2371H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human RPE65 - RPE65-351H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human RPE65, MYC/DDK-tagged - RPE65-246H from Creative Biomart

Category Protein
Source HEK293 cells
Species Human

Recombinant Human Retinoid isomerohydrolase(RPE65) - CSB-YP624103HU CSB-EP624103HU CSB-BP624103HU CSB-MP624103HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

RPE65 - TP310433 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
RPE65

RPE65, Peptide - MBS425335 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Rat, Dog

RPE65 Antibody - SH-A15309 from Novatein Biosciences

Prices $315.00
Sizes 100 µl
Species Human, Mouse, Rat

RPE65 Peptide, Human - M34GP13488H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

RPE65 Immunizing peptide - orb50407 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg

Retinoid isomerohydrolase (RPE65), Recombinant Protein - MBS1364334 from MyBioSource

Category Protein
Prices $1,325.00, $1,325.00, $1,545.00, $1,545.00, $2,185.00, $2,185.00, $2,650.00, $2,650.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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