| Gene Symbol |
FIGF
|
| Entrez Gene |
2277
|
| Alt Symbol |
VEGF-D, VEGFD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
c-fos induced growth factor (vascular endothelial growth factor D)
|
| Other Description |
vascular endothelial growth factor D
|
| Swissprots |
O43915 B2R7Z3
|
| Accessions |
CAA73371 CAH23420 CAI59113 CAI63839 CAI84579 CAJ29849 CAJ32892 CAJ32904 CAL32762 CAV32972 CBH30537 EAW98885 O43915 AJ000185 CAA03942 AK223160 BAD96880 AK313173 BAG35990 BC027948 AAH27948 D89630 BAA24264 DA587496 Y12863 CAA73370 NM_004469 NP_004460
|
| Function |
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269|PubMed:21148085}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway
|