Gene Symbol | FIGF |
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Entrez Gene | 2277 |
Alt Symbol | VEGF-D, VEGFD |
Species | Human |
Gene Type | protein-coding |
Description | c-fos induced growth factor (vascular endothelial growth factor D) |
Other Description | vascular endothelial growth factor D |
Swissprots | O43915 B2R7Z3 |
Accessions | CAA73371 CAH23420 CAI59113 CAI63839 CAI84579 CAJ29849 CAJ32892 CAJ32904 CAL32762 CAV32972 CBH30537 EAW98885 O43915 AJ000185 CAA03942 AK223160 BAD96880 AK313173 BAG35990 BC027948 AAH27948 D89630 BAA24264 DA587496 Y12863 CAA73370 NM_004469 NP_004460 |
Function | Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269|PubMed:21148085}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. |
Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway |
VEGF-D CRISPR/Cas9 KO Plasmid (h) - sc-401669 from Santa Cruz Biotechnology
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VEGF-D HDR Plasmid (h) - sc-401669-HDR from Santa Cruz Biotechnology
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VEGF-D Double Nickase Plasmid (h) - sc-401669-NIC from Santa Cruz Biotechnology
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VEGF-D Double Nickase Plasmid (h2) - sc-401669-NIC-2 from Santa Cruz Biotechnology
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VEGF-D CRISPR Activation Plasmid (h) - sc-401669-ACT from Santa Cruz Biotechnology
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VEGF-D CRISPR Activation Plasmid (h2) - sc-401669-ACT-2 from Santa Cruz Biotechnology
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VEGF-D Lentiviral Activation Particles (h) - sc-401669-LAC from Santa Cruz Biotechnology
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VEGF-D Lentiviral Activation Particles (h2) - sc-401669-LAC-2 from Santa Cruz Biotechnology
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VEGF-D siRNA (h) - sc-39844 from Santa Cruz Biotechnology
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VEGF-D shRNA Plasmid (h) - sc-39844-SH from Santa Cruz Biotechnology
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VEGF-D shRNA (h) Lentiviral Particles - sc-39844-V from Santa Cruz Biotechnology
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VEGF-D RNAi - H00002277-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8693 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8693 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04963 from Sigma-Aldrich
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FIGF siRNA (Human) - CRH1593 from Cohesion Biosciences
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FIGF - MBS8235205 from MyBioSource
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shRNA set against Human FIGF (NM_004469.4) - SHH295001 from Creative biogene
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Rat FIGF siRNA - orb300540 from Biorbyt
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FIGF shRNA Plasmid (Human) - CHH1593 from Cohesion Biosciences
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FIGF miRNA 3'UTR clone - MiUTR3H-02552 from Creative biogene
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