Ikbkb
| Gene Symbol | Ikbkb |
|---|---|
| Entrez Gene | 16150 |
| Alt Symbol | AI132552, IKK-2, IKK-beta, IKK2, IKK[b], IKKbeta |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | inhibitor of kappaB kinase beta |
| Other Description | I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|NFKBIKB|inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta |
| Swissprots | O88351 Q9R1J6 |
| Accessions | EDL32880 EDL32881 O88351 AA203913 AF026524 AAC23557 AF088910 AAD52095 AK003927 AK011359 BAE43224 AK051128 BAC34533 AK053346 AK086442 AK139972 BAE24202 AK144048 AK144603 BAE25962 AK150884 BAE29931 AK151888 AK151955 BAE30827 AK153151 BAE31761 AK155587 AK156294 BAE33659 AK172275 BAE42920 AK177348 AK182153 AK186184 AK194273 AK201390 AK219506 BC004772 AAH04772 BC019210 BC020334 BC037723 AAH37723 BY015258 XM_006509019 XP_006509082 XM_006509020 XP_006509083 XM_006509021 XP_006509084 XM_006509022 XP_006509085 XM_006509023 XP_006509086 XR_870200 NM_001159774 NP_001153246 NM_010546 NP_034676 |
| Function | Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}. |
| Tissue Specificity | Expressed in liver, kidney and spleen. |
| Top Pathways | PI3K-Akt signaling pathway, Small cell lung cancer, Adipocytokine signaling pathway, Acute myeloid leukemia, Epstein-Barr virus infection |
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