Ikbkb

Gene Symbol	Ikbkb
Entrez Gene	16150
Alt Symbol	AI132552, IKK-2, IKK-beta, IKK2, IKK[b], IKKbeta
Species	Mouse
Gene Type	protein-coding
Description	inhibitor of kappaB kinase beta
Other Description	I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|NFKBIKB|inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots	O88351 Q9R1J6
Accessions	EDL32880 EDL32881 O88351 AA203913 AF026524 AAC23557 AF088910 AAD52095 AK003927 AK011359 BAE43224 AK051128 BAC34533 AK053346 AK086442 AK139972 BAE24202 AK144048 AK144603 BAE25962 AK150884 BAE29931 AK151888 AK151955 BAE30827 AK153151 BAE31761 AK155587 AK156294 BAE33659 AK172275 BAE42920 AK177348 AK182153 AK186184 AK194273 AK201390 AK219506 BC004772 AAH04772 BC019210 BC020334 BC037723 AAH37723 BY015258 XM_006509019 XP_006509082 XM_006509020 XP_006509083 XM_006509021 XP_006509084 XM_006509022 XP_006509085 XM_006509023 XP_006509086 XR_870200 NM_001159774 NP_001153246 NM_010546 NP_034676
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}.
Tissue Specificity	Expressed in liver, kidney and spleen.
Top Pathways	PI3K-Akt signaling pathway, Small cell lung cancer, Adipocytokine signaling pathway, Acute myeloid leukemia, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), Mouse, ELISA Kit - SEJ822Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.054ng/mL. Range 0.156-10ng/mL

Inhibitor of nuclear factor kappa-B kinase subunit beta, Ikbkb, Mouse, ELISA Kit - E1953m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Inhibitor of KB Kinase Beta, ELISA Kit - MBS728635 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase Beta, ELISA Kit - MBS741441 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase Beta, ELISA Kit - MBS740692 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase Beta, ELISA Kit - MBS724856 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase beta, ELISA Kit - MBS726413 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)

Inhibitor of KB Kinase Beta, ELISA Kit - MBS720027 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase Beta, ELISA Kit - MBS736682 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Inhibitor of KB Kinase Beta, ELISA Kit - MBS725961 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Inhibitor of KB Kinase Beta, ELISA Kit - MBS739794 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Inhibitor of KB Kinase Beta, ELISA Kit - MBS741855 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of KB Kinase Beta, ELISA Kit - MBS736224 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Inhibitor of KB Kinase Beta, ELISA Kit - MBS734694 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

ELISA Kit for Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) - SEJ822Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, ELISA Kit - MBS9316418 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), Mouse, ELISA Kit - DL-IkBKb-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse IkBKb ELISA Kit - abx570813 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Ikbkb ELISA Kit - E056632 from Biobool Category ELISA Kit

Mouse IKKbeta ELISA Kit - E056642 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

IKBKB ELISA Kit (Mouse) (OKCD02625) - OKCD02625 from Aviva Systems Biology Category ELISA Kit Prices $555.00 Sizes 10 ng Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), ELISA Kit - MBS450025 from MyBioSource Category ELISA Kit Prices $425.00, $560.00, $2,480.00, $4,820.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.054ng/mL Range 0.156-10ng/mL

Inhibitor of nuclear factor kappa-B kinase subunit beta, ELISA Kit - MBS2886451 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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