| Gene Symbol | CFL2 |
|---|---|
| Entrez Gene | 1073 |
| Alt Symbol | NEM7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cofilin 2 (muscle) |
| Other Description | cofilin, muscle isoform|cofilin-2|nemaline myopathy type 7 |
| Swissprots | Q9Y281 G3V5P4 |
| Accessions | AAF64498 AAF97934 EAW65908 EAW65910 EAW65911 EAW65912 Q9Y281 AF087867 AAM10495 AF134802 AAD31280 AF134803 AAD31281 AI754134 AK314157 BAG36842 AL117457 AL599958 BC011444 AAH11444 BC022364 AAH22364 BC022876 AAH22876 BC025683 CB992605 DA298739 DA897112 DB378917 EU832642 ACE87733 EU832719 ACE87051 XM_011536363 XP_011534665 NM_001243645 NP_001230574 NM_021914 NP_068733 NM_138638 NP_619579 NR_028130 NR_028131 |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
| Tissue Specificity | Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. |
| Top Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Pertussis, Regulation of actin cytoskeleton |