| Gene Symbol |
FBXL22
|
| Entrez Gene |
283807
|
| Alt Symbol |
Fbl22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 22
|
| Other Description |
F-box and leucine-rich protein 22|F-box/LRR-repeat protein 22
|
| Swissprots |
Q6P050
|
| Accessions |
EAW77653 Q6P050 AA495872 AK096945 AM392805 CAL37683 AM393002 CAL37880 AM393163 CAL38041 AM393334 CAL38212 AM393873 CAL38748 BC065833 AAH65833 XM_005254320 XP_005254377 XM_006720478 XP_006720541 XM_011521468 XP_011519770 XM_011521469 XP_011519771 XM_011521470 XP_011519772 XM_011521471 XP_011519773 XM_011521472 XP_011519774 NM_203373 NP_976307
|
| Function |
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). {ECO:0000269|PubMed:22972877}.
|
| Subcellular Location |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22972877}.
|
| Tissue Specificity |
Enriched in cardiac muscle. {ECO:0000269|PubMed:22972877}.
|