Gene Symbol | FBXL22 |
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Entrez Gene | 283807 |
Alt Symbol | Fbl22 |
Species | Human |
Gene Type | protein-coding |
Description | F-box and leucine-rich repeat protein 22 |
Other Description | F-box and leucine-rich protein 22|F-box/LRR-repeat protein 22 |
Swissprots | Q6P050 |
Accessions | EAW77653 Q6P050 AA495872 AK096945 AM392805 CAL37683 AM393002 CAL37880 AM393163 CAL38041 AM393334 CAL38212 AM393873 CAL38748 BC065833 AAH65833 XM_005254320 XP_005254377 XM_006720478 XP_006720541 XM_011521468 XP_011519770 XM_011521469 XP_011519771 XM_011521470 XP_011519772 XM_011521471 XP_011519773 XM_011521472 XP_011519774 NM_203373 NP_976307 |
Function | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). {ECO:0000269|PubMed:22972877}. |
Subcellular Location | Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22972877}. |
Tissue Specificity | Enriched in cardiac muscle. {ECO:0000269|PubMed:22972877}. |
FBL22 CRISPR/Cas9 KO Plasmid (h) - sc-415334 from Santa Cruz Biotechnology
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FBL22 HDR Plasmid (h) - sc-415334-HDR from Santa Cruz Biotechnology
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FBL22 Double Nickase Plasmid (h) - sc-415334-NIC from Santa Cruz Biotechnology
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FBL22 Double Nickase Plasmid (h2) - sc-415334-NIC-2 from Santa Cruz Biotechnology
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FBL22 CRISPR Activation Plasmid (h) - sc-415334-ACT from Santa Cruz Biotechnology
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FBL22 CRISPR Activation Plasmid (h2) - sc-415334-ACT-2 from Santa Cruz Biotechnology
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FBL22 Lentiviral Activation Particles (h) - sc-415334-LAC from Santa Cruz Biotechnology
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FBL22 Lentiviral Activation Particles (h2) - sc-415334-LAC-2 from Santa Cruz Biotechnology
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FBL22 siRNA (h) - sc-90049 from Santa Cruz Biotechnology
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FBL22 shRNA Plasmid (h) - sc-90049-SH from Santa Cruz Biotechnology
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FBL22 shRNA (h) Lentiviral Particles - sc-90049-V from Santa Cruz Biotechnology
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FBXL22 RNAi - H00283807-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8525 from Sigma-Aldrich
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FBXL22 siRNA (Human) - CRJ6935 from Cohesion Biosciences
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FBXL22 - MBS8227867 from MyBioSource
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shRNA set against Human FBXL22 (NM_203373.2) - SHH292941 from Creative biogene
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Human FBXL22 siRNA - orb277436 from Biorbyt
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FBXL22 shRNA Plasmid (Human) - CHJ6935 from Cohesion Biosciences
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FBXL22 miRNA 3'UTR clone - MiUTR4H-TG03470 from Creative biogene
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