EXOSC10

Gene Symbol	EXOSC10
Entrez Gene	5394
Alt Symbol	PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
Species	Human
Gene Type	protein-coding
Description	exosome component 10
Other Description	P100 polymyositis-scleroderma overlap syndrome-associated autoantigen|autoantigen PM-SCL|polymyositis/scleroderma autoantigen 100 kDa|polymyositis/scleroderma autoantigen 2
Swissprots	Q01780 B1AKQ1 Q15158 B1AKQ0
Accessions	AAF73199 CAC15569 CAV30720 CAV30721 CCQ43005 EAW71677 EAW71678 EAW71679 Q01780 AB209236 BAD92473 AK093955 AK123365 AK294058 BAG57405 AK296559 BAG59180 AK308778 BC008460 BC009908 AAH09908 BC028687 BC039901 AAH39901 BC073788 AAH73788 CA307576 DA505395 EU832630 ACE87721 EU832705 ACE87037 L01457 AAB59352 X66113 CAA46904 XM_005263475 XP_005263532 XM_005263476 XP_005263533 XM_011541595 XP_011539897 NM_001001998 NP_001001998 NM_002685 NP_002676
Function	Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC10 full length protein - ab152619 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC10 full length protein - ab73483 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human EXOSC10 protein fragment - ab152620 from Abcam Category Protein Source Wheat germ Species Human

EXOSC10 Antibody Blocking Peptide - LS-E14642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Exosome component 10 Protein - H00005394-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Exosome component 10 Protein - H00005394-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EXOSC10 Protein (OPPA01354) - OPPA01354 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 Insect Cells

Human EXOSC10 protein - orb81278 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

EXOSC10 Blocking Peptide - 33R-1070 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC10 Blocking Peptide - 33R-2842 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC10 - H00005394-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EXOSC10 - H00005394-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC10 - H00005394-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Exosome Component 10, Human Recombinant - 228-11281-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Sf9 insect cells. Species Human

Recombinant Human PM/Scl 100 - 228-11281-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human PM/Scl 100 - 228-11281-3 from RayBiotech Category Protein Source Sf9 insect cells. Species Human

EXOSC10 fusion protein - Ag1666 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EXOSC10 fusion protein - Ag10189 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EXOSC10 fusion protein - Ag10318 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Exosome Component 10 Protein - BP001967-PRO-444 from Syd Labs Category Protein Prices $160.00, $3,500.00 Sizes 20 µg, 1 mg Source Sf9 insect cells-derived. Species Human

Recombinant human EXOSC10 - EXOSC10-183H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human EXOSC10, His-tagged - EXOSC10-26640TH from Creative Biomart Category Protein

Recombinant Human EXOSC10, GST-tagged - EXOSC10-12594H from Creative Biomart Category Protein Source E.coli Species Human

EXOSC10 - RP-NKX-999 from Reagent Proteins Category Protein Prices $364.00, $3,668.00 Sizes 20.00 µg, 1 mg Source Sf9 insect cells.

Recombinant Human EXOSC10 His - CRP140A from Cell Science Prices $135.00 Sizes 5 μg Species Human

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