EXOSC10

Gene Symbol EXOSC10
Entrez Gene 5394
Alt Symbol PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
Species Human
Gene Type protein-coding
Description exosome component 10
Other Description P100 polymyositis-scleroderma overlap syndrome-associated autoantigen|autoantigen PM-SCL|polymyositis/scleroderma autoantigen 100 kDa|polymyositis/scleroderma autoantigen 2
Swissprots Q01780 B1AKQ1 Q15158 B1AKQ0
Accessions AAF73199 CAC15569 CAV30720 CAV30721 CCQ43005 EAW71677 EAW71678 EAW71679 Q01780 AB209236 BAD92473 AK093955 AK123365 AK294058 BAG57405 AK296559 BAG59180 AK308778 BC008460 BC009908 AAH09908 BC028687 BC039901 AAH39901 BC073788 AAH73788 CA307576 DA505395 EU832630 ACE87721 EU832705 ACE87037 L01457 AAB59352 X66113 CAA46904 XM_005263475 XP_005263532 XM_005263476 XP_005263533 XM_011541595 XP_011539897 NM_001001998 NP_001001998 NM_002685 NP_002676
Function Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
Top Pathways RNA degradation

EXOSC10 (B-8) - sc-374595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EXOSC10 (B-8): sc-374595. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar localization.

EXOSC10 (E-16) - sc-103488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EXOSC10 (E-16): sc-103488. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing nucleolar, nuclear and cytoplasmic staining of epidermal cells.

EXOSC10 (H-300) - sc-292224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EXOSC10 (H-300): sc-292224. Western blot analysis of EXOSC10 expression in Jurkat (A), K-562 (B), NIH/3T3 (C) and HeLa (D) nuclear extracts.

EXOSC10 (N-14) - sc-103489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EXOSC10 (P-17) - sc-103490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EXOSC10 (A-24) - sc-133569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EXOSC10 (A-24): sc-133569. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human intestine tissue showing cytoplasmic localization.

Anti-EXOSC10 antibody - ab50558 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-EXOSC10 antibody (ab50558) at 1 µg/mlLane 3 : Anti-EXOSC10 antibody (ab50558) at 2 µg/mlLane 1 : HeLa nuclear extract Lane 2 : HeLa nuclear extract with PM/Scl-100 peptideLane 3 : HeLa nuclear extract SecondaryGoat Anti-Rabbit IgG, Peroxidase conjugate with a chemiluminescent substrate.

Anti-EXOSC10 antibody - ab94981 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-EXOSC10 antibody (ab94981) at 1/3000 dilution + 293T whole cell lysate at 30 µg

Anti-EXOSC10 Antibody (aa756-805) - LS-C110495 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
EXOSC10 antibody LS-C110495 Western blot of Transfected 293T cell lysate.

Anti-EXOSC10 Antibody (C-Terminus) - LS-C31532 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
EXOSC10 antibody LS-C31532 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-EXOSC10 Antibody (aa200-250) - LS-C290633 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse EXOSC10 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-EXOSC10 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-EXOSC10 Antibody (clone 1E6) - LS-C197933 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E6
Detection limit for recombinant GST tagged EXOSC10 is approximately 1 ng/ml as a capture antibody.

Anti-EXOSC10 Antibody (aa750-800) - LS-C290634 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EXOSC10 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-EXOSC10 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-EXOSC10 Antibody (aa835-885) - LS-C290635 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EXOSC10 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-EXOSC10 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-EXOSC10 Antibody - LS-C332991 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell lines, using EXOSC10 antibody. .

Exosome component 10 Antibody - NBP1-32870 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 10 Antibody [NBP1-32870] - analysis of EXOSC10 in HeLa whole cell extracts treated with (1) si-control and (2) EXOSC10 siRNA using anti-EXOSC10 antibody. Image from verified customer review.

Exosome component 10 Antibody - NBP1-82448 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 10 Antibody [NBP1-82448] - Analysis in human cell line HEK 293.

Exosome component 10 Antibody - NBP1-82447 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 10 Antibody [NBP1-82447] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY424312)

Exosome component 10 Antibody - NBP1-57184 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Exosome component 10 Antibody - NBP2-16393 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 10 Antibody [NBP2-16393] - Sample (30 ug of whole cell lysate) A: Raji 7. 5% SDS PAGE gel, diluted at 1:1000.

Exosome component 10 Antibody (1E6.) - H00005394-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E6.
ELISA: Exosome component 10 Antibody (1E6.) [H00005394-M08] - Exosome component 10 Antibody (1E6) [H00005394-M08] - Detection limit for recombinant GST tagged EXOSC10 is approximately 1ng/ml as a capture antibody.

EXOSC10/PMSCL2 Polyclonal Antibody - bs-13120R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human skin labeled with Anti-EXOSC10/PMSCL2 Polyclonal Antibody, Unconjugated (bs-13120R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.\\n

EXOSC10/PMSCL2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13120R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EXOSC10/PMSCL2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13120R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EXOSC10/PMSCL2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13120R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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